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Merck
모든 사진(1)

문서

I9032

Sigma-Aldrich

Interferon β from mouse

≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture

동의어(들):

IFN β

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About This Item

MDL number:
UNSPSC 코드:
12352202
NACRES:
NA.32

생물학적 소스

mouse

Quality Level

재조합

expressed in E. coli

분석

≥95%

형태

buffered aqueous solution

분자량

~20 kDa

포장

pkg of 1 vial

농도

2560000 units/mL

기술

cell culture | mammalian: suitable

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−70°C

유전자 정보

mouse ... Ifnb1(15977)

일반 설명

IFN β (interferon β) is from the type 1 interferon family of cytokines.
Interferon β (IFN-β) possesses a signal peptide region. It has comparatively more hydrophobic residues and displays 30% homology with IFN-α.
The gene encoding interferon β (Infb1) is localized on mouse chromosome 4.

애플리케이션

Interferon β from mouse has been used:
  • in the stimulation of bone marrow-derived dendritic cells (BMDCs)
  • as a cytokine to stimulate differentiation of podocytes
  • to stimulate splenocytes

Interferon ß from mouse has been used:
  • to induce the activation of cholesterol 25-hydroxylase, by in vitro stimulation of bone marrow-derived macrophages, dendritic cells and CD11c+ lung macrophages
  • to stimulate splenocytes, in order to study the secretion and regulation of IFN-γ
  • to intranasally pre-treat neonatal mice, to study its effects on the protective actions of Lactobacillus rhamnosus GG (LGG)
  • as a standard to treat MEF-Mx2-luc-BKO reporter cell line for IFN-β measurement, in response to human adenovirus-5 (HAdV-C5)

생화학적/생리학적 작용

In presence of virus infection, IFN β (interferon β) is upregulated and plays a crucial role in innate antiviral response. It is also important for anti-inflammatory effects.
Interferon β (IFN-β) suppresses a variety of proinflammatory cytokines in lymphocytes including the interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α). It also favors the synthesis of antagonists associated with interleukin IL-10 and IL-1 receptor. IFN-β downregulates interferon γ production but enhances transforming growth factor β1 expression. It has therapeutic potential in treating rheumatoid arthritis and relapsing-remitting multiple sclerosis (MS).
Interferon β has a role in the activation of human leukocyte antigen (HLA) gene expression. It acts as a messenger during bacterial infections.
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.

물리적 형태

Solution in 20 mM HEPES, pH 6.0, 0.5 M NaCl, 6% glycerol, and 0.1% bovine serum albumin.

분석 메모

The biological activity is determined in the cytopathic effect inhibition assay using mouse L929 cells with encephalomyocarditis virus. The cytopathic effect of 50% is produced with approximately 1 unit/ml interferon. The units are determined with respect to NIH international standard reference for mouse interferon β.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


시험 성적서(COA)

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Vasco Marcato et al.
Molecular and cellular biology, 36(1), 13-29 (2015-10-16)
Rapid upregulation of interferon beta (IFN-β) expression following virus infection is essential to set up an efficient innate antiviral response. Biological roles related to the antiviral and immune response have also been associated with the constitutive production of IFN-β in
ENU-induced mutation in USP18 causes hyperactivation of IFN-alphabeta signalling and suppresses STAT4-induced IFN-gamma production resulting in increased susceptibility to Salmonella Typhimurium
Richer E, et al.
Journal of immunology (Baltimore, Md. : 1950), 185(6), 3593-3593 (2010)
P Keskinen et al.
Immunology, 91(3), 421-429 (1997-07-01)
HLA class I and II molecules play a central role in regulating host immune responses against microbial infections because they present foreign antigens to CD8+ and CD4+ T lymphocytes, respectively. Many cytokines, especially interferons (IFN), are known to upregulate human
Manuel Hagen et al.
Cell cycle (Georgetown, Tex.), 15(14), 1929-1937 (2016-05-28)
Podocytes are terminally differentiated renal cells, lacking the ability to regenerate by proliferation. However, during renal injury, podocytes re-enter into the cell cycle but fail to divide. Earlier studies suggested that re-entry into cell cycle results in loss of podocytes
Nanthapon Ruangkiattikul et al.
Virulence, 8(7), 1303-1315 (2017-04-20)
Type I interferons (IFN-I), such as IFN-α and IFN-β are important messengers in the host response against bacterial infections. Knowledge about the role of IFN-I in infections by nontuberculous mycobacteria (NTM) is limited. Here we show that macrophages infected with

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