추천 제품
product name
Interferon α 2A human, IFN-α 2A, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
생물학적 소스
human
Quality Level
재조합
expressed in HEK 293 cells
분석
≥95% (SDS-PAGE)
형태
lyophilized powder
효능
≤0.4 ng/mL EC50
품질
endotoxin tested
분자량
monomer 16 kDa (glycosylated)
포장
glass bottle of 10 μg (in glass bottle)
제조업체/상표
HumanZyme
기술
cell culture | mammalian: suitable
불순물
≤1EU/mg
UniProt 수납 번호
저장 온도
−20°C
유전자 정보
human ... IFNA2(3440)
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일반 설명
The IFNA2 (interferon alpha 2) gene is mapped to human chromosome 9p21.3. It is considered to be a prototypic type I IFN subtype. The encoded protein contains 165 amino acid. Ifna2 protein structure possesses five α-helices, linked by two disulfide bonds.
애플리케이션
Interferon α 2A human has been used to check its antiviral action against chikungunya virus. It has also been used as a control to check the antiviral cytokine induction of Korean red ginseng.
생화학적/생리학적 작용
IFNA2 is a type 1 interferon which acts as the first line of defense, and offers protection against pathogenic invasion.
Interferon α 2A (IFN-α 2A) belongs to the type I interferon protein family and is produced by many cell types in response to viral infection. It has antiproliferative and antitumor activities, as well as induction of apoptosis and the inflammatory response. IFN-α 2A enhances the expression of MHC proteins by increasing the presentation of antigen peptides and activates cytotoxic T cells.
물리적 형태
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
제조 메모
HumanKine IFN-α 2A, expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 16 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
분석 메모
The activity is determined by the dose-dependent cytotoxicity of the human TF-1 cell line (human erythroleukemic indicator cell line)) ≤ 0.4.
법적 정보
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
IFNA2: The prototypic human alpha interferon
Paul F, et al.
Gene, 567(2), 132-137 (2015)
Loss of tumor suppressive microRNA-31 enhances TRADD/NF-kappaB signaling in glioblastoma
Rajbhandari R, et al.
Testing, 6(19), 17805-17805 (2015)
Evaluation of broad-spectrum antiviral compounds against chikungunya infection using a phenotypic screening strategy
Bonotto RM, et al.
F1000Research, 7 (2018)
A R Mire-Sluis et al.
Journal of immunological methods, 195(1-2), 55-61 (1996-09-09)
Interferons-alpha and -beta (IFN-alpha and -beta) are cytokines that are widely known to induce potent anti-viral activity. However, it has become increasingly apparent that IFN-alpha and -beta exert a variety of other biological effects, including anti-tumour and immunomodulatory activities and
Evaluation of broad-spectrum antiviral compounds against chikungunya infection using a phenotypic screening strategy
Bonotto RM, et al.
F1000Research, 7 (2018)
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