추천 제품
생물학적 소스
human
Quality Level
재조합
expressed in E. coli
분석
≥95%
형태
buffered aqueous solution
분자량
19 kDa
포장
pkg of 20 μg
농도
≥0.2 mg/mL
기술
cell culture | mammalian: suitable
불순물
endotoxin, tested
색상
colorless
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... IFNA2(3440)
애플리케이션
Interferon-αA human has been used to:
- study the effect of Chikungunya virus on interferon-mediated JAK (Janus kinase)-STAT (signal transducers and activators of transcription) signaling
- study the effect of interferon-α and PRK2 (protein kinase C-related kinase 2) inhibitors on hepatitis C virus replication
- compare the effect of Monascus pigment derivatives on hepatitis C virus replication
생화학적/생리학적 작용
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes) and ruminant embryos (τ subtypes). Interferon induces a variety of effects on target cells including antiviral, antiproliferative and immunomodulatory activities.
물리적 형태
Supplied as a solution in 5 mM sodium acetate, pH 4.0.
분석 메모
The biological activity is determined in the cytopathic effect inhibition assay using MDBK cells with vesicular stomatitis virus (VSV). A cytopathic effect of 50% is produced with 1 unit/ml interferon. The units are determined with respect to WHO International standard reference for human interferonαA.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Jelke J Fros et al.
Journal of virology, 84(20), 10877-10887 (2010-08-06)
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected cells to respond to interferon
S-J Kim et al.
Journal of viral hepatitis, 16(10), 697-704 (2009-02-27)
Hepatitis C virus (HCV) infection is a serious threat to human health worldwide. In spite of the continued search for specific and effective anti-HCV therapies, the rapid emergence of drug-resistance variants has been hampering the development of anti-HCV drugs designed
Ji-Min Sun et al.
The Journal of antimicrobial chemotherapy, 67(1), 49-58 (2011-11-15)
Hepatitis C virus (HCV) infection causes chronic liver disease and is a major public health problem worldwide. The aim of this study was to evaluate the potential of Monascus pigment derivatives, which were derived from a microbial secondary metabolite synthesized
S Rubinstein et al.
Journal of virology, 37(2), 755-758 (1981-02-01)
A convenient assay for interferons based on reduction of cytopathic effect was developed. The number of manipulations and the lengths of the various incubation steps were reduced to a minimum. The assay is simple to perform and can be completed
Shuai Shao et al.
JCI insight, 6(20) (2021-09-08)
Altered epidermal differentiation along with increased keratinocyte proliferation is a characteristic feature of psoriasis and pityriasis rubra pilaris (PRP). However, despite this large degree of overlapping clinical and histologic features, the molecular signatures these skin disorders share are unknown. Using
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