추천 제품
생물학적 소스
human
Quality Level
재조합
expressed in E. coli
분석
≥98% (SDS-PAGE)
양식
lyophilized powder
분자량
~17 kDa
포장
pkg of 0.1 mg
기술
cell culture | mammalian: suitable
불순물
≤1 EU/μg endotoxin
색상
white
solubility
water: soluble 1.000 mL, clear, colorless
UniProt 수납 번호
저장 온도
−20°C
유전자 정보
human ... IFNG(3458)
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애플리케이션
Interferon-γ human has been used:
- to study the effect of interferon-γ on cultured trophoblasts in absence and presence of fibronectin
- to analyse factors which participate in the production of antibody microarrays on glass support
- for ELISA (enzyme-linked immunosorbent assay) method to understand the effect of interferon-γ in human gingival fibroblasts in presence of bacterial challenge
생화학적/생리학적 작용
IFNG (interferon-γ) is a type-2 interferon which is produced by Th (T helper cells)-1 lymphocytes, CD8 cytotoxic lymphocytes, natural killer (NK) cells, and natural killer T (NKT) cells. It plays an important role in innate and adaptive immune responses, and helps in defense against bacterial infections, dimorphic yeast and some viral infections. High expression of IFNG is common in many autoimmune diseases, such as systemic lupus erythematosis, Sjögren syndrome, inflammatory bowel disease and multiple sclerosis.
물리적 형태
Lyophilized from phosphate buffered saline.
분석 메모
The biological activity is measured by a viral resistance assay.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
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이미 열람한 고객
M J Lappin et al.
Archives of oral biology, 61, 36-43 (2015-10-30)
To investigate the potential effects of IFN-03A5 on the responsiveness of human gingival fibroblasts to bacterial challenge. mRNA and protein expression of CD14, TLR2 and TLR4 in human gingival fibroblasts was detected by quantitative polymerase chain reaction (Q-PCR) and flow
R Pijnenborg et al.
Molecular human reproduction, 6(7), 635-641 (2000-06-29)
Tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma, produced by maternal inflammatory cells, may compromise trophoblast survival at the trophoblast-maternal interface and notably in the placental bed which is invaded by trophoblast. Extracellular matrix components, e.g. fibronectin, may enhance trophoblast survival.
Marielle Kaplan et al.
Inflammation, 41(4), 1477-1487 (2018-04-25)
Arterial macrophages comprise a heterogeneous population: pro-inflammatory (M1) and anti-inflammatory (M2). Since C-reactive protein (CRP) is produced by macrophages in atherosclerotic lesions, understanding of CRP regulation in macrophages could be crucial to decipher inflammatory patterns in atherogenesis. We aimed to
Wlad Kusnezow et al.
Proteomics, 3(3), 254-264 (2003-03-11)
Antibody microarrays could have an enormous impact on the functional analysis of cellular activity and regulation, especially at the level of protein expression and protein-protein interaction, and might become an invaluable tool in disease diagnostics. The array surface is bound
K Pfizenmaier et al.
Cancer research, 45(8), 3503-3509 (1985-08-01)
The effect of recombinant gamma-interferon (IFN-gamma) on established human colon carcinoma cell lines as well as fresh tumor cells from colon carcinoma patients has been investigated with respect to growth inhibition, enhancement of HLA expression, and modulation of immunogenicity. A
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