추천 제품
생물학적 소스
human
재조합
expressed in E. coli
분석
≥98% (HPLC)
≥98% (SDS-PAGE)
형태
lyophilized
분자량
31.0 kDa
포장
pkg of 25 μg
기술
cell culture | mammalian: suitable
불순물
<0.1 EU/μg endotoxin, tested
색상
off-white to yellow
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... IL17A(3605)
일반 설명
The gene IL17A (interleukin 17A), also referred to as IL-17, is mapped to human chromosome 6p12.2. The gene contain three exons and encodes a proinflammatory cytokine produced by activated T cells.
생화학적/생리학적 작용
The cytokine interleukin 17A is involved in the activation of proinflammatory cytokines, chemokines, and cell adhesion molecules in several cell types such as, macrophages, dendritic cells, T cells, synovial cells, and endothelial cells. Overexpression of this protein has been associated with rheumatoid arthritis, systemic lupus erythematosus, Behcet′s disease, allograft rejection, nephritic syndrome, asthma, and multiple sclerosis. In mice, it has been observed to be implicated in the development of allergic and autoimmune diseases. Polymorphism in IL17A gene has been associated with lung cancer.
서열
MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
물리적 형태
Lyophilized with no additives.
재구성
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20°C to -80°C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Interleukin-17A and -17F genes polymorphisms in lung cancer.
Kaabachi W
Cytokine, 66, 23-29 (2014)
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis.
Komiyama Y
Journal of Immunology, 177, 566-573 (2006)
Wei Peng et al.
Frontiers in oncology, 12, 781093-781093 (2022-04-12)
This study aimed to investigate the effect of OCT4&SOX2 specific cytotoxic T lymphocytes (CTLs) plus programmed cell death protein-1 (PD-1) inhibitor (nivolumab) on treating breast cancer stem-like cells (BCSCs) in vitro and drug-resistance breast cancer (DRBC) mice in vivo. In
T A Moseley et al.
Cytokine & growth factor reviews, 14(2), 155-174 (2003-03-26)
Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T-cells. Recently discovered related molecules are forming a family of cytokines, the IL-17 family. The prototype member of the family has been designated IL-17A. Due to recent advances in the human
Thomas Fabre et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 3925-3933 (2014-09-12)
Activation of hepatic stellate cells (HSCs) is a key event in the initiation of liver fibrosis, characterized by enhanced extracellular matrix production and altered degradation. Activation of HSCs can be modulated by cytokines produced by immune cells. Recent reports have
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