추천 제품
Quality Level
분석
≥98% (HPLC)
형태
powder
저장 조건
desiccated
색상
white to off-white
solubility
H2O: >10 mg/mL
주관자
Eli Lilly
저장 온도
room temp
SMILES string
Cc1cc(ccc1[C@H](N)C(O)=O)C(O)=O
InChI
1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1
InChI key
SGIKDIUCJAUSRD-QMMMGPOBSA-N
애플리케이션
LY-367385 hydrochloride has been used as a non-N-methyl-D-aspartate (NMDA) glutamate receptor blocker in neuronal stimulation experiment.
생화학적/생리학적 작용
LY-367385 hydrochloride has an ability to inhibit induction of long-term potentiation (LTP).
LY-367385 is a selective metabotropic glutamate 1a receptor (mGlu1a) antagonist.
특징 및 장점
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons
Bonsi P, et al.
Neuropharmacology, 49(5), 104-113 (2005)
Synaptic activity induces input-specific rearrangements in a targeted synaptic protein interaction network
Lautz JD, et al.
Journal of Neurochemistry, 146(5), 540-559 (2018)
D Y Sakae et al.
Molecular psychiatry, 20(11), 1448-1459 (2015-08-05)
Tonically active cholinergic interneurons (TANs) from the nucleus accumbens (NAc) are centrally involved in reward behavior. TANs express a vesicular glutamate transporter referred to as VGLUT3 and thus use both acetylcholine and glutamate as neurotransmitters. The respective roles of each
Miseon Kang et al.
Scientific reports, 10(1), 17921-17921 (2020-10-23)
Abnormally increased neuronal activity in the lateral habenula (LHb) is closely associated with depressive-like behavior. Despite the emphasis on the pathological importance of NMDA receptor (NMDAR)-dependent long-term depression (LTD) and the involvement of calcium permeable AMPA receptor (CP-AMPAR) as major
Michelle Corkrum et al.
Neuron, 105(6), 1036-1047 (2020-01-20)
Dopamine is involved in physiological processes like learning and memory, motor control and reward, and pathological conditions such as Parkinson's disease and addiction. In contrast to the extensive studies on neurons, astrocyte involvement in dopaminergic signaling remains largely unknown. Using
문서
신경과학을 위한 생체 활성 저분자
DISCOVER Bioactive Small Molecules for Neuroscience
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.