M0896

MPTP Hydrochloride

≥98% (AgNO3), powder, dopaminergic neurotoxin

• 동의어(들): MPTP HCl, Pyridine, 1,2,3,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride, MPTP hydrochloride
• 실험식(Hill 표기법): C₁₂H₁₅N · HCl
• CAS Number: 23007-85-4
• Molecular Weight: 209.72
• Beilstein: 3707312
• MDL number: MFCD00012790
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24896578
• NACRES: NA.77

속성

• product name: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride, powder
• 형태: powder
• drug control: kontrollierte Droge in Deutschland
• 색상: white to off-white
• SMILES string: Cl[H].CN1CCC(=CC1)c2ccccc2
• InChI: 1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
• InChI key: KOWJANGMTAZWDT-UHFFFAOYSA-N

설명

일반 설명

MPTP shows its effects by causing inflammation, excitotoxicity, mitochondrial apoptosis, formation of inclusion bodies, and oxidative stress that leads to dopaminergic neuronal damage in the striatum and substantia nigra. In dopaminergic neurons, MPTP blocks the mitochondrial complex I which leads to mitochondrial dysfunction.

애플리케이션

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride has been used to induce Parkinson′s disease (PD) in animal models:

• to study the effect of docosahexaenoic acid on the apelin distribution of the nervous system
• to study the behavioral impairments correlated to neurochemical deficits
• to study the effects of treadmill exercise on neuroprotection and neuroinflammation

MPTP has been used to study its effects on microglial innate immune memory. It has also been used to study the protective effects of phenylpropionamides in Pakinson’s diseased mice models.

생화학적/생리학적 작용

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a piperidine derivative and dopaminergic neurotoxin, useful in neurological research. MPTP is metabolized to 1-methyl-4-phenylpyridine (MPP+), which in turn can cause free radical production in vivo and lead to oxidative stress. Thus MPP+ is generally acknowledged as the active metabolite of MPTP. MPTP is widely used in in vivo research studies as a model for Parkinsonism. A review describes the application of MPTP in studies related to programmed cell death in neurogenerative diseases.

Dopaminergic neurotoxin.

경고

Reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H301,H370
• 예방조치 성명서: P260 - P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - STOT SE 1
• 표적 기관: Nervous system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3