M3199
MK-212 hydrochloride
≥98% (HPLC)
동의어(들):
2-Chloro-6-(1-piperazinyl)-pyrazine hydrochloride, 6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride, NSC 31732
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C8H11ClN4·HCl
CAS Number:
Molecular Weight:
235.11
EC Number:
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
분석
≥98% (HPLC)
형태
powder
저장 조건
desiccated
색상
white to off-white
solubility
DMSO: ≥20 mg/mL
저장 온도
2-8°C
SMILES string
Cl.Clc1cncc(n1)N2CCNCC2
InChI
1S/C8H11ClN4.ClH/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13;/h5-6,10H,1-4H2;1H
InChI key
PFIZGLUIYAZQFU-UHFFFAOYSA-N
생화학적/생리학적 작용
Selective 5-HT2C serotonin receptor agonist.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Oral
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Nathan S Pentkowski et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35(10), 2037-2048 (2010-06-04)
Serotonin 2C receptor (5-HT(2C)R) agonists administered systemically attenuate both cocaine-primed and cue-elicited reinstatement of extinguished cocaine-seeking behavior. To further elucidate the function of these receptors in addiction-like processes, this study examined the effects of microinfusing the 5-HT(2C)R agonist MK212 (0
Janet L Neisewander et al.
Behavioural pharmacology, 18(8), 791-800 (2007-11-09)
The extinction/reinstatement model has been used in this study to examine the role of 5-HT2C receptors in cocaine-seeking behavior elicited by cocaine-associated cues and cocaine-priming injections. Rats that had been trained to press a lever for cocaine (0.75 mg/kg/0.1 ml
K S Gomes et al.
Progress in neuro-psychopharmacology & biological psychiatry, 33(7), 1261-1269 (2009-07-25)
A single exposure to the elevated plus-maze test (EPM) increases open arms avoidance and reduces or abolishes the anxiolytic-like effect of benzodiazepines assessed during a second trial, a phenomenon defined as "one-trial tolerance" (OTT). It has been emphasized that the
Antonio Pedro de Mello Cruz et al.
Psychopharmacology, 182(3), 345-354 (2005-09-01)
Although 5-HT2 receptors seem to play an important role in anxiety, results from numerous studies are still highly variable. Moreover, little is known about the behavioral effects of centrally administered 5-HT2 compounds in animal models of anxiety. The current study
M L Pierce et al.
Neuroscience, 170(3), 827-838 (2010-07-24)
Neuronal networks generating rhythmic activity as an emergent property are common throughout the nervous system. Some are responsible for rhythmic behaviours, as is the case for the spinal cord locomotor networks; however, for others the function is more subtle and
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