R5010

Resveratrol

≥99% (HPLC)

• 동의어(들): 3,4′,5-Trihydroxy-trans-stilbene, 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol
• 실험식(Hill 표기법): C₁₄H₁₂O₃
• CAS Number: 501-36-0
• Molecular Weight: 228.24
• MDL number: MFCD00133799
• UNSPSC 코드: 12352205
• PubChem Substance ID: 24278055
• NACRES: NA.25

속성

• 생물학적 소스: plant root (bushy knotweed)
• 분석: ≥99% (HPLC)
• 형태: powder
• solubility: acetone: 50 mg/mL, clear, faintly yellow
• 응용 분야: metabolomics; vitamins, nutraceuticals, and natural products
• 저장 온도: −20°C
• SMILES string: Oc1ccc(cc1)\C=C\c2cc(O)cc(O)c2
• InChI: 1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
• InChI key: LUKBXSAWLPMMSZ-OWOJBTEDSA-N
• 유전자 정보: human ... AR(367) , CYP1A2(1544) , ESR1(2099) , SIRT1(23411) ; mouse ... Nos2(18126) ; rat ... Esr1(24890)

설명

애플리케이션

Resveratrol has been used:

• in entrapment experiment
• to study its neuroprotective effect on retinal neuronal cell death mediated by diabetes-induced activation of Ca²⁺/calmodulin-dependent protein kinase II
• as a standard in the assessment of stilbene content in grapevine leaf by in vivo fluorometry

Selective inhibitor of COX−1.

생화학적/생리학적 작용

Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD⁺)-dependent histone deacetylase involved in mitochondrial biogenesis and the enhancement of peroxisome proliferator-g-activated receptor coactivator-1a (PGC-1a) and FOXO (forkhead box) activity. The anti-diabetic, neuroprotective and anti-adipogenic actions of resveratrol may be mediated via SIRT1 activation. Resveratrol has antiviral action against Herpes simplex virus-1 (HSV1) and HSV2. It also exhibits antitumor and phytoestrogenic biological activities. Resveratrol is known to prolong life in many species by mediating several physiological events.

제조 메모

Soluble in ethanol, DMSO, and acetone. Only very slightly soluble in water (3 mg/100 mL).

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H319
• 예방조치 성명서: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): >392.0 °F - closed cup - (External MSDS)
• Flash Point (°C): > 200.0 °C - closed cup - (External MSDS)
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves