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Merck
모든 사진(1)

문서

M3903

Sigma-Aldrich

Methoxypolyethylene glycol p-nitrophenyl carbonate

average mol wt 5,000

동의어(들):

Methoxy PEG Nitrophenyl Carbonate, Methoxypoly(ethylene glycol) nitrophenyl carbonate, Polyethylene glycol, mPEG-NPC

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About This Item

MDL number:
UNSPSC 코드:
12161900
NACRES:
NA.25

분자량

average mol wt 5,000

Quality Level

저장 온도

−20°C

일반 설명

Methoxypolyethylene glycol p-nitrophenyl carbonate is a polyethylene glycol (PEG) derivative. PEGs are widely used as a covalent modifier of biologic macromolecules and particulates and for mechanism of drug delivery.

애플리케이션

Methoxypolyethylene glycol p-nitrophenyl carbonate has been used in a study to obtain unimolecular dendritic micelles designed as solubility enhancers. It has also been used in a study to investigate the properties of lipase from Candida rugosa modified with Mpeg. It is also useful for modification of proteins.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

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문서 라이브러리 방문

Hu Yang et al.
Journal of colloid and interface science, 273(1), 148-154 (2004-03-31)
Unimolecular dendritic micelles designed as solubility enhancers were obtained by coupling polyethylene glycol (PEG) to Starburst polyamidoamine (PAMAM) dendrimers. Micelles-750, -2000, and -5000 have a generation 3.0 dendrimer core (32 primary amine end groups) and PEG arms with molecular weights
Properties of methoxy(polyethylene glycol)-lipase from Candida rugosa in organic solvents
Zacchigna, M., et al.
Il Farmaco Ed. Sc., 53, 758-758 (1998)
F M Veronese et al.
Applied biochemistry and biotechnology, 11(2), 141-152 (1985-04-01)
A single-step method of activation of monomethoxypolyethylene glycols suitable for its binding to polypeptides and proteins is proposed. Based on the reaction with 2,4,5-trichlorophenylchloroformate or p-nitrophenylchloroformate, it gives reactive PEG-phenylcarbonate derivatives. The PEG intermediate is stable on storage, the activating
Chemistry of polyethylene glycol conjugates with biologically active molecules
Zalipsky, S., et al.
Advanced Drug Delivery Reviews, 16, 157-157 (1995)

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