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MTOX1016

Sigma-Aldrich

OATP1B3 Knockout HepaRG™ Cells

human female liver (hepatocarcinoma and hepatitis C tumor)

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About This Item

UNSPSC 코드:
12352207
NACRES:
NA.81

제품명

OATP1B3 Knockout HepaRG™ Cells, 1 vial

생물학적 소스

human female liver (hepatocarcinoma and hepatitis C tumor)

Quality Level

200

양식

liquid

OMIM 수납 번호

605495

저장 온도

−196°C

유전자 정보

human ... OATP1B3(28234)

일반 설명

HepaRG is a human hepatoma cell line. The cells possess a pseudodiploid karyotype and have been characterized as an oval ductular bipotent hepatic cell line as they have the ability to differentiate into both biliary and hepatocyte lineages in the presence of DMSO. HepaRG OATP1B3 knockout cells express the major xenobiotic sensors (PXR, CAR and AhR), drug transporters, phase I and II drug metabolizing enzymes as well as key hepatic transcription factors involved in stress response pathways.

애플리케이션

See technical bulletin for detailed protocols

특징 및 장점

Zinc finger nucleases (ZFN) mediated Knock-out of SLCO1B3 (MRP3) gene.

  • The frame-shift mutation of SLCO1B3 gene was confirmed by fragment length analysis and DNA sequencing.
  • Loss of functionality was confirmed by loss of transport of selective substrates in sandwich culture assay.

품질

Tested for Mycoplasma, sterility, post-freeze viability, short terminal repeat (STR) analysis for cell line identification, cytochrome oxidase I (COI) analysis for cell line species confirmation.

법적 정보

These products are covered by the License Agreement as described in Exhibit 1, 2 and 3, in the technical bulletin.
HepaRG is a trademark of BioPredic International company

면책조항

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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