N0165

Nisoldipine

≥98% (HPLC)

• 동의어(들): (±)-Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate, 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-methylpropyl ester, Sular
• 실험식(Hill 표기법): C₂₀H₂₄N₂O₆
• CAS Number: 63675-72-9
• Molecular Weight: 388.41
• EC Number: 264-407-7
• MDL number: MFCD00478055
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329818405
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: yellow
• solubility: DMSO: >10 mg/mL
• 주관자: Bayer
• 저장 온도: room temp
• SMILES string: COC(=O)C1=C(C)NC(C)=C(C1c2ccccc2[N+]([O-])=O)C(=O)OCC(C)C
• InChI: 1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3
• InChI key: VKQFCGNPDRICFG-UHFFFAOYSA-N
• 유전자 정보: human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

설명

애플리케이션

Nisoldipine has been used:

• as a hit-antagonist to study its effects on oxytocin (OT)-induced myometrial Ca²⁺-mobilization and its potency to dampen uterine myometrial contractions
• as a calcium channel blocker to study its effects on cell viability in a human hepatic cancer HepG2 and rat renal epithelial NRK52E cell line
• as a component of the external IK1 recording solution to study the action potential in human pluripotent stem cell−derived cardiomyocytes (hiPS-CMs)

생화학적/생리학적 작용

L-type (CaV1.2) calcium channel blocker; dihydropyridine-type calcium channel blocker with selectivity for smooth muscle (CaV1.2b) over cardiac muscle (CaV1.2a). Arterial vasodilator and antihypertensive agent.

특징 및 장점

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable