N1628

Novobiocin sodium salt

≥90% (HPLC)

• 동의어(들): Albamycin, Albamycin Sodium, Cathomycin sodium
• 실험식(Hill 표기법): C₃₁H₃₅N₂NaO₁₁
• CAS Number: 1476-53-5
• Molecular Weight: 634.61
• Beilstein: 3892910
• EC Number: 216-023-6
• UNSPSC 코드: 51286504
• PubChem Substance ID: 24897508
• NACRES: NA.85

속성

• 생물학적 소스: (STREPTOMYCES NIVEUS)
• Quality Level: 200
• 분석: ≥90% (HPLC)
• 양식: powder
• 저장 조건: (Tightly closed. Dry. )
• 색상: white to yellow
• 항생제 활성 스펙트럼: Gram-positive bacteria
• 동작 모드: DNA synthesis | interferes; enzyme | inhibits
• 저장 온도: 2-8°C
• SMILES string: [Na+].CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3C([O-])=C(NC(=O)c4ccc(O)c(C\C=C(\C)C)c4)C(=O)Oc3c2C)OC1(C)C
• InChI: 1S/C31H35N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34,36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q-1;+1
• InChI key: AXOUUAINTJNFRS-UHFFFAOYSA-N

설명

일반 설명

Novobiocin sodium salt is an antibiotic derived from soil bacteria. Novobiocin inhibits the action of bacterial DNA gyrase and belongs to a class of compounds called coumarin antibiotics. Coumarins are heterocyclic compounds with a wide range of biological activity, including antibacterial, anticoagulant, antioxidant, anti-inflammatory, antiviral, antitumor, and enzyme inhibitory effects.

애플리케이션

For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.

Novobiocin Sodium Salt, an inhibitor of Hsp90, can be used:

• in the research heat shock protein inhibition and to produce positively supercoiled plasmid DNA
• in the research on the efficacy of probiotics
• in the research on the efficacy of human monocytes and dendritic cells for T-cell replication

생화학적/생리학적 작용

Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.
Antimicrobial spectrum: Gram-positive bacterial.

Novobiocin inhibits DNA synthesis by inhibiting the GyrB subunit of the Topoisomerase enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB.

특징 및 장점

High quality antibiotic suitable for mulitple research applications

저장 및 안정성

Stored in frozen aliquots, Keep container tightly closed in a dry and well-ventilated place. Light sensitive

기타 정보

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안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H317,H319
• 예방조치 성명서: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves