추천 제품
Quality Level
분석
≥98% (HPLC)
형태
solid
색상
white
solubility
DMSO: >20 mg/mL at 60 °C
H2O: insoluble
저장 온도
2-8°C
SMILES string
CCCN(CC1CC1)c2nc(C)nc(Nc3c(Cl)cc(Cl)cc3Cl)c2Cl
InChI
1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
InChI key
KNADXBVKFAUMCR-UHFFFAOYSA-N
유전자 정보
human ... CRHR1(1394)
애플리케이션
NBI 27914 has been used as acorticotropin-releasing hormone receptor (CRHR1) antagonist:
- to study its effects on steroidogenic gene expression in GD15 mouse testis
- to study its effects on amyloid β production
- to study its effects on neurogenic activity of neural stem cells in the adult hippocampus
생화학적/생리학적 작용
NBI 27914 is a CRF1 corticotropin-releasing factor receptor antagonist.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus
Koutmani Y, et al.
Testing, 29(4), 932-945 (2019)
A transcriptome-wide screen for mRNAs enriched in fetal Leydig cells: CRHR1 agonism stimulates rat and mouse fetal testis steroidogenesis
McDowell E N, et al.
PLoS ONE, 7(10), e47359-e47359 (2012)
The stress response neuropeptide CRF increases amyloid-beta production by regulating gamma-secretase activity
Park H J, et al.
The Embo Journal, 34(12), 1674-1686 (2015)
Takatoshi Kasai et al.
Cell reports, 30(1), 18-24 (2020-01-09)
The pituitary is a major hormone center that secretes systemic hormones responding to hypothalamus-derived-releasing hormones. Previously, we reported the independent pituitary induction and hypothalamic differentiation of human embryonic stem cells (ESCs). Here, a functional hypothalamic-pituitary unit is generated using human
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