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Merck
모든 사진(1)

주요 문서

N4007

Sigma-Aldrich

N-Nitroso-N-methylbutylamine

동의어(들):

Methylbutylnitrosamine

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About This Item

실험식(Hill 표기법):
C5H12N2O
CAS Number:
Molecular Weight:
116.16
MDL number:
UNSPSC 코드:
12352116
PubChem Substance ID:
NACRES:
NA.25

형태

liquid

Quality Level

density

0.93 g/mL (lit.)

저장 온도

2-8°C

SMILES string

CCCCN(C)N=O

InChI

1S/C5H12N2O/c1-3-4-5-7(2)6-8/h3-5H2,1-2H3

InChI key

PKTSCJXWLVREKX-UHFFFAOYSA-N

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포장

Bulk package

픽토그램

Skull and crossbonesHealth hazard

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 3 Oral - Carc. 1B

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


시험 성적서(COA)

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문서 라이브러리 방문

Q Huang et al.
Cancer letters, 69(2), 107-116 (1993-04-30)
We studied the metabolism of methyl-n-butyl-nitrosamine (MBN), a carcinogen for the rat esophagus and liver. The 2-, 3- and 4-hydroxy derivatives were identified as new metabolites of MBN. In studies on tissue slices freshly removed from MRC-Wistar rats, MBN metabolism
M Lee et al.
Cancer research, 49(6), 1470-1474 (1989-03-15)
Metabolic activation may be a key step in determining the tissue specificity of carcinogenic nitrosamines. In previous work, we characterized P450IIE1 (an acetone/ethanol-inducible form of cytochrome P-450) as the major enzyme for the metabolic activation of N-nitrosodimethylamine. In this work
Nozomi Tsutsumi et al.
Bioorganic & medicinal chemistry, 18(23), 8284-8288 (2010-10-30)
N-Nitrosodialkylamines are known to be potent indirect-acting mutagens/carcinogens, which are activated by cytochrome P450. The reaction product of N-nitroso-N-methylbutylamine (NMB) with modified Fenton's reagent supplemented with copper salt (Fe²(+)-Cu²(+)-H₂O₂) was reported to be mutagenic in Salmonella typhimurium TA1535 without S9
T Gichner et al.
Mutagenesis, 1(2), 107-109 (1986-03-01)
The organic solvents dimethylsulphoxide (DMSO), acetone, ethanol and dimethylformamide inhibited the mutagenic activity of the promutagens dimethylnitrosamine and methylbutylnitrosamine in a higher plant Arabidopsis thaliana. In contrast, the direct-acting mutagens N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and N-methyl-N-nitrosourea (MNU) were not affected by the
W Lijinsky et al.
Journal of cancer research and clinical oncology, 106(3), 171-175 (1983-01-01)
The carcinogenic effectiveness of nitrosomethyl-n-butylamine,-n-hexylamine and -n-heptylamine was compared by administration to F344 rats at various concentrations in drinking water and by gavage in oil. Nitrosomethylbutylamine induced only tumors of the upper gastrointestinal tract, and was very toxic. Nitrosomethylhexylamine was

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