N5636

3-Nitropropionic acid

≥97% (HPLC), powder or crystals, mitochondrial complex II inhibitor

• Linear Formula: O₂N(CH₂)₂CO₂H
• CAS Number: 504-88-1
• Molecular Weight: 119.08
• Beilstein: 1759889
• EC Number: 208-003-0
• MDL number: MFCD00007406
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278593
• NACRES: NA.77

속성

• product name: 3-Nitropropionic acid, ≥97%
• 생물학적 소스: synthetic
• 분석: ≥97%
• 형태: powder or crystals
• 색상: white to light yellow
• mp: 68-70 °C (lit.)
• solubility: alcohol: may be light yellow 100 mg/mL
• 저장 온도: 2-8°C
• SMILES string: OC(CC[N+]([O-])=O)=O
• InChI: 1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)
• InChI key: WBLZUCOIBUDNBV-UHFFFAOYSA-N

설명

애플리케이션

3-Nitropropionic acid has been used:

• to generate multiple system atropy-parkinsoniam (MSA-P) model in rat to evaluate its effect on embryonic striatal and mesencephalic grafts
• to inject into the nigrostriatal dopaminergic pathway in rats in order to examine its specific effects on the dopamine system
• as succinate dehydrogenase (SDH) inhibitor for LUHMES neurons and cell lines

생화학적/생리학적 작용

Administering 3-nitropropionic acid (3-NP) to the inner ear can stimulate sensorineural hearing loss. It serves as an irreversible inhibitor of mitochondrial complex II.

Excitotoxin shown to cause brain lesions similar to those of Huntington′s disease.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P301 + P330 + P331 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges