P1269

Phorbol 12,13-dibutyrate

≥98% (TLC), powder, PKC activator

• 동의어(들): PDBu
• 실험식(Hill 표기법): C₂₈H₄₀O₈
• CAS Number: 37558-16-0
• Molecular Weight: 504.61
• Beilstein: 6551234
• MDL number: MFCD00036783
• UNSPSC 코드: 12352211
• PubChem Substance ID: 24898178
• NACRES: NA.77

속성

• product name: Phorbol 12,13-dibutyrate, ≥98% (TLC), powder
• Quality Level: 100
• 분석: ≥98% (TLC)
• 형태: powder
• 색상: clear light yellow, film
• solubility: H₂O: 30 μM; DMSO: soluble; acetone: soluble; ethanol: soluble
• 저장 온도: −20°C
• SMILES string: CCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@@H](C=C(CO)C[C@@]3(O)[C@H]2C=C(C)C3=O)[C@@H]4C(C)(C)[C@]14OC(=O)CCC
• InChI: 1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1
• InChI key: BQJRUJTZSGYBEZ-YVQNUNKESA-N
• 유전자 정보: mouse ... Prkcd(18753)

설명

애플리케이션

Phorbol 12,13-dibutyrate has been used as a protein kinase C (PKC) activator to study its effects on human organic anion transporter 4 (hOAT4) activity. It has also been used as a PKC activator to analyze its effects on galectin-3 expression and matrix production in HL-1 cells.

생화학적/생리학적 작용

Phorbol 12,13-dibutyrate (PDBu) is a potent activator of protein kinase C (PKC). It is more hydrophilic than phorbol 12-myristate 13-acetate (PMA), which facilitates washing PDBu out of cells in tissue culture. PDBu activates endothelial nitric oxide synthase expression in primary human umbilical vein endothelial cells, which in turn correlates with PKC α and ε expression.

특징 및 장점

Less hydrophobic then PMA, making it easier to wash out of cells in tissue culture.

주의사항

Photosensitive

재구성

Stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.

안전성 정보

• 픽토그램: GHS06,GHS08,GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H300 + H310 + H330,H314,H317,H334,H351
• 예방조치 성명서: P202 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves