P3134

Phosphodiesterase I from Crotalus adamanteus venom

Type VI, crude dried venom

• 동의어(들): 5′-Exonuclease, Oligonucleate 5′-nucleotidohydrolase
• CAS Number: 9025-82-5
• 효소 위원회 번호: 3.1.4.1 (BRENDA, IUBMB)
• EC Number: 232-806-5
• MDL number: MFCD00131883
• UNSPSC 코드: 12352204
• NACRES: NA.54

속성

• 유형: Type VI
• Quality Level: 200
• 형태: crude dried venom
• 저장 온도: −20°C

설명

일반 설명

Research area: Cell signaling. PhosphodiesteraseI (PDEI) exists in three isoforms PDE1A, PDE1B, and PDE1C(2) are localized to the central nervous system, cardiovascular, and other organs.

애플리케이션

Phosphodiesterase I from Crotalus adamanteus venom has been used:

• for cleaving the 3′-5′ internucleotide bonds in the linear chains of the RNA oligomers
• as a model for the hydrolysis of prodrugs in phosphodiesterase assay
• as a component in the nucleotide cleavage buffer

생화학적/생리학적 작용

Phosphodiesterase I breaks phosphodiester bonds and catalyzes the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is released from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C. PhosphodiesteraseI (PDEI) can hydrolyze 3′,5′-cyclic adenosine monophosphate (cAMP) and3′,5′-cyclic guanosine monophosphate (cGMP). It binds to Ca²⁺/calmodulin(CaM) that lead to the stimulation of its catalytic activity.PDEIacts as a biotherapeutic for the treatment of cancer, heart diseases,pulmonary, metabolic, neurocognitive, renal, endocrine abnormalities, andneurological disorders.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H334
• 예방조치 성명서: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable