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P4020

Sigma-Aldrich

Protamine sulfate

amorphous powder

동의어(들):

Salmine, Salmine from salmon

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About This Item

CAS Number:
53597-25-4
MDL number:
MFCD00132091
UNSPSC 코드:
12352202
NACRES:
NA.77
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제품명

Protamine sulfate salt from salmon, Grade X, amorphous powder

유형

Grade X

Quality Level

200

양식

amorphous powder

불순물

histone, free (Millon test)

색상

white to off-white

solubility

6 M HCl: 25 mg/mL

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일반 설명

Protamine are proteins rich in cysteine and arginine.[1] It possesses many phosphorylation sites.[2] It is found to be localized to the sperm head.[3]

애플리케이션

May be used for the removal of DNA from protein samples or for the purification of DNA binding proteins. It may be used as an alternative to polybrene in retroviral-mediated gene transfer.

Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamine sulfate salt from salmon has been used:
  • in the pretreament of cells to study its effect on respiratory syncytial virus infection[4]
  • in lentivirus production[5]
  • to derivatize it into a diazeniumdiolate NO donor[6]

생화학적/생리학적 작용

Protamine sulfate is a small cationic protein that binds and precipitates DNA. Neutralizes the anticoagulant activity of heparin. Inhibits lipoprotein lipase.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
0000371991
0000371992
0000321788
0000321787
0000321774

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이미 열람한 고객

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1 of 2

Surfen hydrate ≥98% (HPLC)

Sigma-Aldrich

S6951

Surfen hydrate

Sequa-brene gelatinous solid

Sigma-Aldrich

S2667

Sequa-brene

Iduronic acid-containing glycosaminoglycans on target cells are required for efficient respiratory syncytial virus infection
Hallak LK, et al.
Virology, 271(2), 264-275 (2000)
Diazeniumdiolation of protamine sulfate reverses mitogenic effects on smooth muscle cells and fibroblasts
Van Lith R, et al.
Free radical biology & medicine, 82, 13-21 (2015)
Peter V Hauser et al.
PloS one, 5(3), e9463-e9463 (2010-03-09)
Podocytes are injured in several glomerular diseases. To alter gene expression specifically in podocytes in vivo, we took advantage of their active endocytotic machinery and developed a method for the targeted delivery of small interfering ribonucleic acids (siRNA). We generated
Wenjie Ouyang et al.
Human gene therapy, 32(9-10), 481-494 (2020-12-02)
β-Thalassemia is one of the most prevalent genetic diseases worldwide. The current treatment for β-thalassemia is allogeneic hematopoietic stem cell transplantation, which is limited due to lack of matched donors. Gene therapy has been developed as an alternative therapeutic option
The design and evaluation of heparin-binding foldamers.
Sungwook Choi et al.
Angewandte Chemie (International ed. in English), 44(41), 6685-6689 (2005-08-12)
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