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P4505

Sigma-Aldrich

Protamine sulfate salt from herring

Grade III, histone, free(Millon test)

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Synonym(s):
Clupeine
CAS Number:
MDL number:
NACRES:
NA.77

biological source

fish (herring)

Quality Level

type

Grade III

form

powder

impurities

histone, free (Millon test)

solubility

6 M HCl: 25 mg/mL, clear, colorless to very faintly yellow

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This Item
P4380P4020P4005
Protamine from salmon Grade IV, Histone, free(Millon test)

Sigma-Aldrich

P4005

Protamine from salmon

form

powder

form

powder

form

amorphous powder

form

solid

solubility

6 M HCl: 25 mg/mL, clear, colorless to very faintly yellow

solubility

6 M HCl: 25 mg/mL, clear, colorless to light yellow

solubility

6 M HCl: 25 mg/mL

solubility

H2O: soluble, clear to slightly hazy, colorless to faintly yellow

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

type

Grade III

type

Grade II

type

Grade X

type

Grade IV

impurities

histone, free (Millon test)

impurities

-

impurities

histone, free (Millon test)

impurities

Histone, free (Millon test)

Application

May be used for the removal of DNA from protein samples or for the purification of DNA binding proteins. It may be used as an alternative to polybrene in retroviral-mediated gene transfer.

Biochem/physiol Actions

Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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A Bonincontro et al.
Physics in medicine and biology, 34(5), 609-616 (1989-05-01)
The complex dielectric constant of arginine and protamine from herring sperm (clupeine) and their complexes with herring sperm DNA was measured at 10 GHz in the temperature range -20 to +45 degrees C by a microwave cavity perturbation method. The
C Toniolo et al.
Biochimica et biophysica acta, 576(2), 429-439 (1979-02-26)
The three main components YI, YII, and Z of clupeine, a protamine from herring, have been purified and characterized. The conformational preferences of clupeines have been examined as a funciton of pH, temperature, added salts, and presence of structure-disrupting agents
I Saiki et al.
Japanese journal of cancer research : Gann, 81(6-7), 668-675 (1990-06-01)
We have investigated the anti-angiogenic effect of a polymeric peptide based on the Arg-Gly-Asp (RGD) core sequence of fibronectin as a monomer unit, i.e., poly(RGD), in syngeneic mice and in vitro. Single intratumoral administration of poly(RGD) on day 0, 1
L Ferrara et al.
European journal of biochemistry, 126(2), 389-394 (1982-08-01)
The three main fractions of clupeine, the protamine extracted from herring sperm, have been investigated by 13C nuclear magnetic resonance techniques. The dynamic behaviour, examined through the evaluation of the spin lattice relaxation times (T1) of individual carbon resonances assigned
G M Bonora et al.
European journal of biochemistry, 93(1), 13-21 (1979-01-02)
The three main components (called YI, YII and Z) of clupeine a protamine from herring have been isolated and characterized by 13C nuclear magnetic resonance. Resonance belonging to the many different amino acid carbon atoms are observable and assigned. The

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