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P4380

Sigma-Aldrich

Protamine sulfate salt from salmon

Grade II

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Synonym(s):
Salmine, Salmine from salmon
CAS Number:
MDL number:
NACRES:
NA.77

biological source

fish (salmon)

Quality Level

type

Grade II

form

powder

color

white to off-white

solubility

6 M HCl: 25 mg/mL, clear, colorless to light yellow

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This Item
P4020P4005P3369
Protamine from salmon Grade IV, Histone, free(Millon test)

Sigma-Aldrich

P4005

Protamine from salmon

Protamine sulfate meets USP testing specifications

Sigma-Aldrich

P3369

Protamine sulfate

form

powder

form

amorphous powder

form

solid

form

solid

color

white to off-white

color

white to off-white

color

-

color

-

solubility

6 M HCl: 25 mg/mL, clear, colorless to light yellow

solubility

6 M HCl: 25 mg/mL

solubility

H2O: soluble, clear to slightly hazy, colorless to faintly yellow

solubility

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

type

Grade II

type

Grade X

type

Grade IV

type

-

General description

Protamine sulfate (PS), a polycationic, positively charged protein is mostly made up of poly(l-arginine). It is obtained from salmon sperm protein.

Application

Protamine sulfate salt from salmon has been used in the generation of protamine silica nanocomposites.
May be used for the removal of DNA from protein samples or for the purification of DNA binding proteins. It may be used as an alternative to polybrene in retroviral-mediated gene transfer.

Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.

Biochem/physiol Actions

Protamine sulfate is highly preferred in cardiovascular surgical procedures to reverse the anticoagulant properties of heparin. It is used for biomedical and biotechnological applications due to its biodegradablity.
Protamine sulfate is a small cationic protein that binds and precipitates DNA. Neutralizes the anticoagulant activity of heparin. Inhibits lipoprotein lipase.

Quality

May contain insolubles as well as histones.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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