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SAE0112

Sigma-Aldrich

β2-Microglobulin from human urine

≥98% (SDS-PAGE), solution

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Synonym(s):
β2-Microglobulin from human urine
MDL number:

assay

≥98% (SDS-PAGE)

form

solution

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... B2M(567)

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MSST0015MSST0016SAB4200785
form

solution

form

lyophilized powder

form

lyophilized powder

form

buffered aqueous solution

Gene Information

human ... B2M(567)

Gene Information

human ... B2M(567)

Gene Information

human ... B2M(567)

Gene Information

human ... B2M(567)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

UniProt accession no.

P61769

UniProt accession no.

P61769

UniProt accession no.

P61769

UniProt accession no.

P61769

Application

β2-Microglobulin from human urine was used to test humoral CSF parameters in the differential diagnosis of hematologic CNS neoplasia. It was also used in the identification of CTL epitopes in hepatitis C virus by a genome-wide computational scanning and a rational design of peptide vaccine.

Biochem/physiol Actions

β2 microglobulin (β2-M) is a polypeptide that associates with the heavy chain of class I major histocompatibility complex (MHC) antigens on the cell surface. The interaction is dynamic and plays a critical role in the stability of the MHC antigens and their ability to present peptide antigens in CD8+ cells. A transient complex of MHC heavy chain and β2-M is known to be assembled into the TAP molecule (transporter associated with antigen processing) through interactions with a number of chaperones. Binding of processed peptide releases the Class I-β2-M complex to the cell surface. Absence of binding leads to degradation in the proteasome.

Preparation Note

Prepared by the method of Berggard and Bearn.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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