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Merck
모든 사진(1)

Key Documents

P4247

Sigma-Aldrich

Anti-Potassium Channel Kv1.3 (extracellular)−FITC antibody produced in rabbit

affinity isolated antibody, lyophilized powder

동의어(들):

Anti-Kcna3, Anti-Voltage-gated Potassium Channel KV1.3

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About This Item

MDL number:
UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

결합

FITC conjugate

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

lyophilized powder

종 반응성

rat, human, mouse

기술

flow cytometry: 0.5-5 μg/test using Jurkat T-cells
western blot: 1:200-1:500 using rat brain membranes

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... KCNA3(3738)
mouse ... Kcna3(16491)
rat ... Kcna3(29731)

일반 설명

The (K+) channel family has been sub-grouped in to 2 TM, 4 TM and 6 TM (K+) channels based on the number of transmembrane domains. The voltage-gated Potassium or (Kv) channels belong to the 6 TM (K+) channel family and are expressed mainly in hematopoietic cells such as T and B lymphocytes, macrophages and natural killer cells. (Kv)1.3 facilitates cell proliferation and can also regulate the immune system. Genetic alterations in (Kv) 1.3 lead to epilepsy, episodic ataxia/myokymia, and episodic cardiac arrhythmia (the long QT syndrome). Anti-potassium channel (Kv) 1.3 (extracellular)−FITC antibody can be used for western blotting of rat brain membranes. Rabbit anti- potassium channel (Kv) 1.3 (extracellular) antibodies reacts specifically with rat and human (Kv) 1.3.

면역원

synthetic peptide corresponding to residues 211-224 of human KV1.3. Rat and mouse are 12/14 residues identical.

애플리케이션

Anti-potassium channel (Kv) 1.3 (extracellular)−FITC antibody can be used in immunoblotting and flow cytometry.

물리적 형태

Lyophilized from phosphate buffered saline, pH 7.4, 1% bovine serum albumin, 0.05% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

R S Lewis et al.
Annual review of immunology, 13, 623-653 (1995-01-01)
Over the past decade, a variety of ion channels have been identified and characterized in lymphocytes by use of the patch-clamp technique. This review discusses biophysical and regulatory aspects of lymphocyte potassium and calcium channels with the aim of understanding
Ildiko Szabo et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 37(3), 965-978 (2015-09-24)
Pharmacological inhibition of the potassium channel Kv1.3 has been shown to selectively kill B cells from patients with chronic lymphocytic leukemia (B-CLL). Here we aimed to biophysically characterize and compare Kv1.3 channel activity in B cells isolated either from healthy
George A Gutman et al.
Pharmacological reviews, 55(4), 583-586 (2003-12-06)
This summary article presents an overview of the molecular relationships among the voltage-gated potassium channels and a standard nomenclature for them, which is derived from the IUPHAR Compendium of Voltage-Gated Ion Channels. The complete Compendium, including data tables for each
Gergely Toldi et al.
International immunology, 22(9), 769-774 (2010-07-06)
Cytokine production in activated T lymphocytes of the term neonate is reduced compared with adults. We aimed to characterize the calcium influx kinetics of activated T lymphocytes in the neonate and to test the functionality and expression of Kv1.3 and

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