P9767

Sodium palmitate

≥98.5%

• 동의어(들): Hexadecanoic acid sodium salt, Palmitic acid sodium salt
• Linear Formula: CH₃(CH₂)₁₄COONa
• CAS Number: 408-35-5
• Molecular Weight: 278.41
• Beilstein: 3575882
• EC Number: 206-988-1
• MDL number: MFCD00002749
• UNSPSC 코드: 12352211
• PubChem Substance ID: 24899061
• NACRES: NA.25

속성

• 생물학적 소스: plant (palm)
• 분석: ≥98.5%
• 형태: powder
• mp: 283-290 °C (lit.)
• 작용기: ester
• 지질 유형: saturated FAs
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: [Na+].CCCCCCCCCCCCCCCC([O-])=O
• InChI: 1S/C16H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18;/h2-15H2,1H3,(H,17,18);/q;+1/p-1
• InChI key: GGXKEBACDBNFAF-UHFFFAOYSA-M

설명

애플리케이션

Sodium palmitate (PA) has been used:

• to induce inflammation and thrombosis pathway in murine macrophage cell line RAW 264.7 cell line by activating reactive oxygen species (ROS) production, Janus-kinase (JNK) signalling and release of histone H3 by western blotting and cell viability by MTT assay
• to induce lipogenesis in AML12 cells and primary hepatocytes to analyse the effect of irisin on PA induced lipogenesis and related signal pathways by western blot analysis and quantitative PCR analysis
• as a component in free fatty acid mixture to induce cellular steatosis in HepG2 cell lines and determination of lipid accumulation by Oil-Red-O staining

생화학적/생리학적 작용

Sodium palmitate is the sodium salt of palmitic acid, a component in hard soaps. Palmitic acid is a common saturated fatty acid and produced during fatty acid synthesis. Sodium palmitate enhances lipogenesis, cellular steatosis in various cell lines. Palmitate induces cell death in human epidermal growth factor receptor 2 (HER2)/neu-positive cells and breast cancer cell lines like MCF-7 due to enhanced fatty acid accumulation. Sodium palmitate induces lipoapoptosis in L02 and HepG2 liver cells by inducing glycogen synthase kinase-3β (GSK3β) expression.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves