PZ0250

PF-04859989 hydrochloride

≥98% (HPLC)

• 동의어(들): (3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one; L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride, PF-4859989 hydrochloride, PF04859989 hydrochloride
• 실험식(Hill 표기법): C₉H₁₀N₂O₂ · HCl
• CAS Number: 177943-33-8
• Molecular Weight: 214.65
• MDL number: MFCD22419400
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329823792
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: white to beige
• solubility: H₂O: 20 mg/mL, clear
• 저장 온도: room temp
• SMILES string: N[C@H]1CC2=CC=CC=C2N(O)C1=O.Cl
• InChI: 1S/C9H10N2O2.ClH/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12;/h1-4,7,13H,5,10H2;1H/t7-;/m0./s1
• InChI key: WZOBDOKCHIUXAY-FJXQXJEOSA-N

설명

생화학적/생리학적 작용

PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid, which has been implicated in several psychiatric and neurological disorders, including schizophrenia and bipolar disorder, and thought to impair cognitive function. PF-04859989 has IC₅₀ values of 23 nM for hKAT II and 263 nM for rKAT II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 prevented ketamine-induced disruption of performance in memory tasks in both rodents and nonhuman primates.

특징 및 장점

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안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable