S1442

Sordarin sodium salt

from Sordaria araneosa, ≥98% (HPLC), solid

• 실험식(Hill 표기법): C₂₇H₃₉NaO₈
• CAS Number: 463356-00-5
• Molecular Weight: 514.58
• MDL number: MFCD08277029
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24899480
• NACRES: NA.77

속성

• 생물학적 소스: Sordaria araneosa
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 형태: solid
• solubility: H₂O: soluble ≤10 mg/mL
• 항생제 활성 스펙트럼: fungi
• 동작 모드: protein synthesis | interferes
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: [Na+].[H]C(=O)[C@]12C[C@]3([H])C=C(C(C)C)[C@@]1(C([O-])=O)[C@]3(CO[C@@H]4O[C@H](C)[C@@H](OC)[C@@H](O)[C@@H]4O)C[C@]5([H])[C@H](C)CC[C@@]25[H]
• InChI: 1S/C27H40O8.Na/c1-13(2)19-8-16-9-25(11-28)18-7-6-14(3)17(18)10-26(16,27(19,25)24(31)32)12-34-23-21(30)20(29)22(33-5)15(4)35-23;/h8,11,13-18,20-23,29-30H,6-7,9-10,12H2,1-5H3,(H,31,32);/q;+1/p-1/t14-,15-,16+,17-,18-,20+,21+,22-,23-,25+,26+,27+;/m1./s1
• InChI key: ILUKWKGTAAZHDW-IGICPMPSSA-M

설명

애플리케이션

Soradrin sodium salt has been used as an antifungal compound to treat mycelia for immunofluorescence microscopy studies. It may be used in in vitro diphtheria toxin sensitivity assays.

생화학적/생리학적 작용

Sordarin is an antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The elongation factor EF-2 is the molecular target for sordarin. It blocks ribosomal translocation by stabilizing the EF2-ribosome complex in a manner similar to that of fusidic acid in the bacterial system. Additional cellular components (including rpP0, which is an essential protein of the ribosomal large subunit stalk) are involved in its mechanism of action. Sordarin inhibits in vitro translation in the pathogenic fungi C. albicans, C. glabrata, and C. neoformans. In addition to its therapeutic potential, sordarin is a useful tool for the analysis of protein translation events.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)