S3134

Streptokinase from β-hemolytic Streptococcus (Lancefield Group C)

lyophilized powder, ≥2,000 units/mg solid

• 동의어(들): Streptokinase from Streptococcus hemolyticus
• CAS Number: 9002-01-1
• 효소 위원회 번호: 3.4.99.0 (BRENDA, IUBMB)
• EC Number: 232-647-1
• MDL number: MFCD00082037
• UNSPSC 코드: 12352204
• eCl@ss: 32160410
• NACRES: NA.54

속성

• 양식: lyophilized powder
• Quality Level: 200
• 특이 활성도: ≥2,000 units/mg solid
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: N1C(CC(C1)C2CCCCC2)C(=O)O
• InChI: 1S/C11H19NO2/c13-11(14)10-6-9(7-12-10)8-4-2-1-3-5-8/h8-10,12H,1-7H2,(H,13,14)
• InChI key: XRZWVSXEDRYQGC-UHFFFAOYSA-N

설명

일반 설명

Research area: Cell signaling

Streptokinase is an extracellular enzyme produced by β-hemolytic Streptococcus. It is a single-chain polypeptide enzyme that consists of multiple structural domains, including α-, β-, and γ-domains.

애플리케이션

Streptokinase has been used in a study to compare primary coronary intervention and thrombolytic therapy in myocardial infarction patients.

Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare.

생화학적/생리학적 작용

Streptokinase is a potent plasminogen activator. Unlike human proteins tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), microbial streptokinase does not directly activate plasminogen. Instead, it activates plasminogen by fibrin-dependent and fibrin-independent. mechanisms. Streptokinase is effective in thrombolytic therapy. While streptokinase offers promising potential in treating ischemic stroke, its use also presents a significant risk of intracerebral hemorrhage. Streptokinase is also used in treating complicated parapneumonic effusions and empyema where allergic reactions, are rare.

단위 정의

One unit is equal to the amount of activity in one unit from a Streptokinase International Standard reference vial.

물리적 형태

Lyophilized powder containing ~50% total protein by biuret and sodium glutamate. Total protein composed of enzyme protein and human serum albumin.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable