추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen ~100 kDa
종 반응성
human
농도
~1.0 mg/mL
기술
immunoprecipitation (IP): 2-5 μg using lysate of human MCF-7 cells
indirect immunofluorescence: 2-4 μg/mL
western blot: 0.5-1.0 μg/mL using whole extracts of human MCF-7 cells
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... SEL1L(6400)
일반 설명
SEL1L (Sel-1-like) is a type I transmembrane glycoprotein, that is located in ER (endoplasmic reticulum). It is considered as a putative tumor suppressor gene. It is located on chromosome 14q.
SEL1L is highly expressed in the pancreas.
애플리케이션
Anti-SEL1L (N-terminal) antibody produced in rabbit has been used in
- immunoblotting
- immunoprecipitation
- immunofluorescence
생화학적/생리학적 작용
SEL1L (Sel-1-like) participates in the degradation pathway linked with endoplasmic reticulum (ER), malignant transformation and stem cells. It helps in the self regeneration of the neural stem cell. It controls cell fate developmental decision and homeostasis. It plays an important role in retaining homeostasis of endoplasmic reticulum throughout embryonic growth of vertebrate.
SEL1L is involved in cell growth and cancer progression.
물리적 형태
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
가장 최신 버전 중 하나를 선택하세요:
A single-nucleotide polymorphism in tumor suppressor gene SEL1L as a predictive and prognostic marker for pancreatic ductal adenocarcinoma in Caucasians
Liu Q, et al.
Molecular Carcinogenesis, 51(5), 433-438 (2012)
SEL1L a multifaceted protein playing a role in tumor progression
Biunno I, et al.
Journal of Cellular Physiology, 208(1), 23-38 (2006)
SEL1L SNP rs12435998, a predictor of glioblastoma survival and response to radio-chemotherapy
Mellai M, et al.
Oncotarget, 6(14), 12452-12467 (2015)
Guido J Breedveld et al.
Neurogenetics, 11(4), 417-423 (2010-05-04)
Tourette syndrome (TS) is a frequent neuropsychiatric disorder of unknown etiology. A number of chromosomal regions have been nominated as TS loci in linkage studies, but confirmation has met with limited success and causative mutations have not yet been definitely
Rong Du et al.
BMC cancer, 21(1), 237-237 (2021-03-08)
Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal cancers, is driven by oncogenic KRAS mutations. Farnesyl thiosalicylic acid (FTS), also known as salirasib, is a RAS inhibitor that selectively dislodges active RAS proteins from cell membrane, inhibiting downstream signaling.
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