S4441

D,L-Sulforaphane

≥90% (HPLC), liquid, phase II detoxification enzymes inducer

• 동의어(들): 1-Isothiocyanato-4-(methylsulfinyl)-butane
• 실험식(Hill 표기법): C₆H₁₁NOS₂
• CAS Number: 4478-93-7
• Molecular Weight: 177.29
• MDL number: MFCD00198068
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24724610
• NACRES: NA.77

속성

• 제품명: DL-Sulforaphane, ≥90% (HPLC), synthetic, liquid
• 생물학적 소스: synthetic
• Quality Level: 200
• 분석: ≥90% (HPLC)
• 양식: liquid
• solubility: DMSO: soluble 40 mg/mL; H₂O: insoluble
• 호환성: for use with ABI 7500
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: CS(=O)CCCCN=C=S
• InChI: 1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
• InChI key: SUVMJBTUFCVSAD-UHFFFAOYSA-N

설명

애플리케이션

LNCaP prostate cancer cells were treated with DL-Sulforaphane to study the effect on androgen receptor. Effects on malathion toxicity was studied in rats by treating them with DL-Sulforaphane.

생화학적/생리학적 작용

Selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.

Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables. It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)