추천 제품
생물학적 소스
mouse
Quality Level
결합
unconjugated
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
Syn211, monoclonal
형태
buffered aqueous solution
분자량
antigen 19 kDa
종 반응성
zebra finch, human
반응하면 안 됨
rat, mouse
포장
antibody small pack of 25 μL
농도
~1 mg/mL
기술
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 0.25 μg/mL using recombinant human α·-synuclein.
동형
IgG1
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... SNCA(6622)
일반 설명
The SNCA (synuclein α) gene codes for a 140-amino acid protein α-synuclein, that is mapped to human chromosome 4q21-23.
The SNCA (synuclein α) gene is mapped to human chromosome 4q22.1. The gene encodes a small synaptic protein called α-synuclein.
면역원
recombinant human α synuclein.
애플리케이션
Anti-α-Synuclein antibody, Mouse monoclonal has been used in western blotting and ELISA.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Flow cytometry/Cell sorting (1 paper)
Immunocytochemistry (1 paper)
Flow cytometry/Cell sorting (1 paper)
Immunocytochemistry (1 paper)
생화학적/생리학적 작용
Accumulation of α-synuclein in oligodendrocytes results in the loss of myelin and causes neurodegeneration, leading to multiple system atrophy. Synuclein-α is known to induce oligodendrocyte maturation. The encoded protein is considered to be an important aggregate of Lewy bodies, contributing to the pathogenesis of Parkinson disease.
Synuclein-α is known to induce oligodendrocyte maturation. Accumulation of α-synuclein in oligodendrocytes results in the loss of myelin and causes neurodegeneration, leading to multiple system atrophy. Mutations in the SNCA gene results in Parkinson′s disease.
물리적 형태
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 1 % bovine serum albumin and 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Kavita Prasad et al.
Brain pathology (Zurich, Switzerland), 22(6), 811-825 (2012-03-29)
The role of Lewy bodies, Lewy neurites and α-synuclein (αSYN) in the pathophysiology and diagnosis of Parkinson's disease (PD) is unclear. We used postmortem human tissue, a panel of antibodies (Abs) and confocal microscopy to examine the three-dimensional neurochemical anatomy
Regional deficiencies in chaperone-mediated autophagy underlie α-synuclein aggregation and neurodegeneration
Malkus KA, et al.
Neurobiology of Disease, 46(3), 732-744 (2012)
α-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication.
Miller DW, et al.
Neurology, 62(10), 1835-1838 (2004)
Sabrina Büttner et al.
The EMBO journal, 32(23), 3041-3054 (2013-10-17)
Malfunctioning of the protein α-synuclein is critically involved in the demise of dopaminergic neurons relevant to Parkinson's disease. Nonetheless, the precise mechanisms explaining this pathogenic neuronal cell death remain elusive. Endonuclease G (EndoG) is a mitochondrially localized nuclease that triggers
Interactions of Pathological Hallmark Proteins
Olah J, et al.
The Journal of Biological Chemistry, 286(39), 34088-34100 (2011)
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