S6135

Somatostatin 28

≥97% (HPLC)

• 동의어(들): Prosomatostatin
• 실험식(Hill 표기법): C₁₃₇H₂₀₇N₄₁O₃₉S₃
• CAS Number: 73032-94-7
• Molecular Weight: 3148.56
• MDL number: MFCD00076772
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24899687
• NACRES: NA.32

속성

• Quality Level: 200
• 분석: ≥97% (HPLC)
• 양식: powder
• 분자량: 3148.56
• 저장 조건: (Keep container tightly closed in a dry and well-ventilated place)
• 농도: >70% (peptide content)
• 기술: activity assay: suitable
• solubility: water: 1 mg/mL, clear, colorless
• UniProt 수납 번호: P61278
• 저장 온도: −20°C
• SMILES string: CSCCC(NC(=O)C(C)NC(=O)C1CCCN1C(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(C)NC(=O)C(N)CO)C(=O)NC(C)C(=O)N2CCCC2C(=O)NC(CCCNC(N)=N)C(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NCC(=O)NC3CSSCC(NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc4ccccc4)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(Cc5c[nH]c6ccccc56)NC(=O)C(Cc7ccccc7)NC(=O)C(Cc8ccccc8)NC(=O)C(CC(N)=O)NC(=O)C(CCCCN)NC3=O)C(C)O)C(C)O)C(O)=O
• InChI: 1S/C137H207N41O39S3/c1-69(154-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)156-114(195)88(46-54-218-7)158-110(191)71(3)155-129(210)100-42-28-53-178(100)134(215)95(61-104(144)186)171-126(207)96(65-180)172-124(205)93(59-102(142)184)165-111(192)70(2)153-112(193)80(141)64-179)109(190)152-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(58-78-62-151-81-36-18-17-35-79(78)81)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(60-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139/h8-18,29-36,62,69-74,80,82-101,107-108,151,179-183H,19-28,37-61,63-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,152,190)(H,153,193)(H,154,194)(H,155,210)(H,156,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150)
• InChI key: GGYTXJNZMFRSLX-UHFFFAOYSA-N
• 유전자 정보: human ... SST(6750)

설명

Amino Acid Sequence

Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys [Disulfide Bridge: 17-28]

일반 설명

Research area: Neuroscience

The SST gene is mapped to human chromosome 3q27.3. Both SST-14 and SST-28 are cyclic peptide.

The somatostatin gene codes for a peptide hormone containing 14 and 28 amino acid moieties. SST-14 is highly expressed in the central nervous system and peripheral organs. SST-28 is mainly expressed in enteroendocrine cells of the intestine.

애플리케이션

Somatostatin 28 has been used:

• to study the effects of somatostatin in regulating hepatic growth hormone sensitivity
• to study its effects on insulin-like growth factor-I receptor expression in the gills of Oncorhynchus mykiss (a teleost fish)
• to assess the effects of somatostatinon GH (growth hormone)-stimulated IGF-I (insulin-like growth factor-I) expression

생화학적/생리학적 작용

Somatostatin action is delivered with help of five different receptor subtypes (sst1 to sst5).

Somatostatin plays an important role in regulating the metabolism of other hormones such as growth hormone, insulin, IGF-1 (insulin-like growth factor 1), glucagon, glucagon-like peptide and gastrin. Somatostatin has both regulatory and inhibitory functions. It retards gastrointestinal motility and gallbladder contraction, suppresses gut exocrine secretion and reduces epithelial proliferation. Somatostatin is associated with intestinal nutrient absorption and blood flow regulation. This peptide hormone is believed to inhibit cell proliferation and promote apoptosis. Somatostatin acts as a neurotransmitter and neuromodulator, and is also associated in maintaining water balance.Pituitary somatostatin receptor signaling is implicated in the inhibition of adenylyl cyclase- cyclic adenosine 3′,5′-monophosphate (cAMP)- protein kinase A (PKA) pathway. Pituitary somatostatin activity is also involved in regulation of various pathways including guanylyl cyclase and nitric oxide (NO), mitogen-activated protein kinase (MAPK) and protein kinase B (PI3K/Akt).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)