S8626

Sulfadiazine

99.0-101.0%

• 동의어(들): 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide, N¹-(Pyrimidin-2-yl)sulfanilamide
• 실험식(Hill 표기법): C₁₀H₁₀N₄O₂S
• CAS Number: 68-35-9
• Molecular Weight: 250.28
• Beilstein: 6733588
• EC Number: 200-685-8
• MDL number: MFCD00006065
• UNSPSC 코드: 51283908
• PubChem Substance ID: 24899802
• NACRES: NA.85

속성

• 설명: Solubility - Practically insoluble in water, slightly soluble in acetone, very slightly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides and in dilute mineral acids.
• Quality Level: 200
• 분석: 99.0-101.0%
• 형태: powder or crystals
• 색상: white to faint yellow, faint pink
• mp: 253 °C (dec.) (lit.)
• solubility: 96% ethanol: very slightly soluble; acetone: slightly soluble; water: practically insoluble
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria; mycoplasma
• 동작 모드: DNA synthesis | interferes; enzyme | inhibits
• SMILES string: Nc1ccc(cc1)S(=O)(=O)Nc2ncccn2
• InChI: 1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
• InChI key: SEEPANYCNGTZFQ-UHFFFAOYSA-N

설명

일반 설명

Chemical structure: sulfonamide

애플리케이션

Sulfadiazine is a short-acting sulfonamide that is commonly used with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome. It is also used to treat newborns with congenital infections. Sulfadiazine has been used to control acute infections when studying murine models of reactivated toxoplasmosis.

생화학적/생리학적 작용

Sulfadiazine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

기타 정보

Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids

안전성 정보

• 픽토그램: GHS08,GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H302,H361d,H411
• 예방조치 성명서: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves