SAB1300113
Anti-TGFBR1 (center) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
동의어(들):
TGF-β receptor type I, TGFR-1, TGF-β type I receptor, Serine/threonine-protein kinase receptor R4, SKR4, Activin receptor-like kinase 5, ALK-5
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모든 사진(3)
About This Item
UNSPSC 코드:
12352203
NACRES:
NA.41
추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
IgG fraction of antiserum
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
종 반응성
human, mouse
기술
immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
western blot: 1:100-1:500
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... TGFBR1(7046)
일반 설명
TGFBR1 (transforming growth factor β receptor 1) gene is mapped to human chromosome 9q22.33. TGFBR1 is known to localize in the focal adhesions of the cell surface.
The protein encoded by this gene forms a heteromeric complex with type II TGF-β receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
면역원
TGFBR1 (NP_004603, 138-173)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human TGFBR1.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human TGFBR1.
애플리케이션
Anti-TGFBR1 (center) antibody produced in rabbit has been used in western blot.
생화학적/생리학적 작용
TGFBR1 (transforming growth factor β receptor 1) stimulates signaling pathway that mediates cell growth and division. The complex formed by TGFBR2 with TGFBR1 results in the phosphorylation and activation of TGFBR1. TGFBR1 is responsible for the activation of canonical Smad (mothers against decapentaplegic homolog 3) proteins and transcriptional factors Snail (zinc finger protein) and Twist (twist family bHLH transcription factor 1). The activation of a number of non-canonical effectors such as RhoA (ras homolog family member A), TAK1 (transforming growth factor-β-activated kinase 1) and Akt (RAC-α serine/threonine-protein kinase) is also associated with TGFBR1. The arrangement of the TGFBR1 receptor along with TGFBR2 at the focal adhesions mediates the multimerization and stimulation of TGFβ ligand. Downregulation of TGFBR1 is observed in breast cancer. TGFBR1 is also known to be associated with colorectal cancer.
물리적 형태
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Ibrahim Y Hachim et al.
Human pathology, 57, 140-151 (2016-10-25)
The transforming growth factor-β (TGFβ) plays a dual role in breast cancer, acting as a tumor suppressor in early carcinomas while promoting tumor metastasis in more advanced breast carcinoma. As a result, the prognostic role of TGFβ and its signaling
Rosa M Xicola et al.
Carcinogenesis, 37(8), 751-758 (2016-05-29)
The purpose of this study was to identify novel colorectal cancer (CRC)-causing alleles in unexplained familial CRC cases. In order to do so, coding regions in five candidate genes (MGMT, AXIN2, CTNNB1, TGFBR1 and TGFBR2) were sequenced in 11 unrelated
Sergiy Klid et al.
Stem cell research & therapy, 12(1), 608-608 (2021-12-22)
An environment of gestational diabetes mellitus (GDM) can modify the phenotype of stem cell populations differentially according to their placental localization, which can be useful to study the consequences for the fetus. We sought to explore the effect of intrauterine
Iqra Mushtaq et al.
iScience, 27(6), 110084-110084 (2024-06-17)
The mutated SCN5A gene encoding defective Nav1.5 protein causes arrhythmic ailments and is associated with enhanced cardiac fibrosis. This study investigated whether SCN5A mutation directly affects cardiac fibroblasts and explored how defective SCN5A relates to cardiac fibrosis. SCN5A knockdown (SCN5AKD)
Li Yang et al.
PloS one, 11(5), e0155270-e0155270 (2016-05-14)
Endometrial cancer (EC) is a complex disease involving multiple gene-gene and gene-environment interactions. TGF-β signaling plays pivotal roles in EC development. This study aimed to investigate whether the genetic polymorphisms of TGF-β signaling related genes TGFB1, TGFBR1, SNAI1 and TWIST1
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