추천 제품
생물학적 소스
goat
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
종 반응성
rat
기술
indirect ELISA: suitable
western blot: suitable
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... GFAP(2670)
관련 카테고리
일반 설명
Goat polyclonal anti-GFAP antibody reacts with rat, canine, human, and mouse glial fibrillary acidic proteins.
Intermediate filaments (IFs) with characteristic 10 nm diameter are a distinct class of molecularly heterogenous cytoskeletal filaments defined by ultrastructural, immunological, and biochemical criteria. Intermediate filaments differ significantly from the other cytoskeletal elements of the cell, namely microtubules and microfilaments, and are components of most eukaryotic cells. Glial Fibrillary Acidic Protein (GFAP) (molecular weight of 50 kDa) is found in astrocytes and ependymal cells of the central nervous system. It is found in various other cell types including stellate cells, chondrocytes, osteocytes, keratinocytes, Leydig cells and fibroblasts. GFAP is involved in mitosis, and cell:cell interactions and communications.
면역원
Peptide with sequence C-DGEVIKESKQEHKD from the C Terminus of the protein sequence according to NP_002046.1.
애플리케이션
Goat polyclonal anti-GFAP antibody is used to tag glial fibrillary acidic protein for detection and quantitation by Western blotting and immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of glial fibrillary acidic protein in cell:cell communications, mitosis and cell structure. Anti-GFAP has proven a valuable tool for use in immunocytochemical localization of GFAP in normal central nervous system tissue, certain tumors and metastases of the glial antigen, as well as for immunofluorescent labeling of cultured mammalian cells.
생화학적/생리학적 작용
Glial fibrillary acidic protein (GFAP) is associated with tumor progression of brain neoplasms and increase expression of this gene is observed in brain tumor. Gfap maintains cell stability and shape. Damage to the central nervous system (CNS) increases the levels of circulation Gfap. Gfap mediates cell migration, development, mitosis and signaling in astrocytes and a some glial cells. Mutation in GFAP gene is involved in neural dysfunction disease and Alexander disease characterized by the accumulation of Rosenthal fibers.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
적합한 제품을 찾을 수 없으신가요?
당사의 제품 선택기 도구.을(를) 시도해 보세요.
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Post-mortem serum concentrations of GFAP correlate with agony time but do not indicate a primary cerebral cause of death
Breitling B, et al.
Testing, 13(10), e0205323-e0205323 (2018)
Emerson Krock et al.
Osteoarthritis and cartilage, 26(9), 1236-1246 (2018-06-18)
Intervertebral disc degeneration is a leading cause of chronic low back pain (LBP) but current treatment is limited. Toll-like receptors (TLRs) on disc cells are activated by endogenous extracellular matrix (ECM) fragments and modulate degeneration in vitro. This study investigated whether
Corinne Orlemann et al.
Advanced healthcare materials, 13(15), e2304169-e2304169 (2024-02-07)
Brain interfaces that can stimulate neurons, cause minimal damage, and work for a long time will be central for future neuroprosthetics. Here, the long-term performance of highly flexible, thin polyimide shanks with several small (<15 µm) electrodes during electrical microstimulation of
A novel functional polymorphism of GFAP decrease glioblastoma susceptibility through inhibiting the binding of miR-139
Wang J, et al.
Aging, 10(5), 988-988 (2018)
Crystal structure of the human glial fibrillary acidic protein 1B domain
Kim B, et al.
Biochemical and biophysical research communications, 503(4), 2899-2905 (2018)
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.