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Merck
모든 사진(1)

주요 문서

G4546

Sigma-Aldrich

Anti-Glial Fibrillary Acidic Protein Antibody

rabbit polyclonal

동의어(들):

GFAP Antibody for Flow Cytometry - Anti-Glial Fibrillary Acidic Protein antibody produced in rabbit, Gfap Antibody Flow Cytometry, Anti-FLJ45472, Anti-GFAP, Anti-Intermediate filament protein

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About This Item

MDL number:
UNSPSC 코드:
12352203
NACRES:
NA.41

결합:
unconjugated
application:
FACS
IHC
WB
클론:
polyclonal
종 반응성:
human, rat, mouse
citations:
37
기술:
flow cytometry: 1:200-1:500
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000

제품명

Anti-Glial Fibrillary Acidic Protein antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

양식

buffered aqueous solution

분자량

antigen ~50 kDa

종 반응성

human, rat, mouse

일반 설명

Intermediate filaments (IFs) with characteristic 10 nm diameter are a distinct class of molecularly heterogenous cytoskeletal filaments defined by ultrastructural, immunological, and biochemical criteria. Intermediate filaments differ significantly from the other cytoskeletal elements of the cell, namely microtubules and microfilaments, and are components of most eukaryotic cells. Glial Fibrillary Acidic Protein (GFAP) (molecular weight of 50 kDa) is found in astrocytes and ependymal cells of the central nervous system. It is found in various other cell types including stellate cells, chondrocytes, osteocytes, keratinocytes, Leydig cells and fibroblasts. GFAP is involved in mitosis, and cell:cell interactions and communications. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system.

특이성

Rabbit polyclonal anti-Glial Fibrillary Acidic Protein recognizes human, mouse, and rat GFAPs.

면역원

synthetic peptide corresponding to an internal C-terminal sequence of human GFAP.

애플리케이션

Rabbit polyclonal anti-GFAP antibody is used to tag glial fibrillary acidic protein for detection and quantitation by Western blotting and immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of glial fibrillary acidic protein in cell:cell communications, mitosis and cell structure. Anti-GFAP has proven a valuable tool for use in immunocytochemical localization of GFAP in normal central nervous system tissue, certain tumors and metastases of the glial antigen, as well as for immunofluorescent labeling of cultured mammalian cells.

물리적 형태

solution in phosphate buffered saline, containing 0.02% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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문서 라이브러리 방문

Jesús Agulla et al.
Theranostics, 4(1), 90-105 (2014-01-08)
The use of theranostics in neurosciences has been rare to date because of the limitations imposed on the free delivery of substances to the brain by the blood-brain barrier. Here we report the development of a theranostic system for the
Christopher G Dengler et al.
Scientific reports, 7, 42090-42090 (2017-02-22)
In a mouse model of temporal lobe epilepsy, multicellular calcium imaging revealed that disease emergence was accompanied by massive amplification in the normally sparse, afferent stimulation-induced activation of hippocampal dentate granule cells. Patch recordings demonstrated reductions in local inhibitory function
Maha Saber et al.
Journal of neurotrauma, 34(2), 423-435 (2016-03-16)
Traumatic brain injury (TBI) affects 1.7 million persons annually in the United States (Centers for Disease Control and Prevention). There is increasing evidence that persons exposed to TBI have increased risk of the development of multiple neurodegenerative conditions, including Alzheimer
G F Hamilton et al.
Neuroscience, 265, 274-290 (2014-02-12)
Neonatal alcohol exposure impairs cognition and learning in adulthood and permanently damages the hippocampus. Wheel running (WR) improves hippocampus-associated learning and memory and increases the genesis and survival of newly generated neurons in the hippocampal dentate gyrus. WR significantly increases
Smriti M Agrawal et al.
Brain : a journal of neurology, 136(Pt 6), 1760-1777 (2013-05-21)
Inflammatory perivascular cuffs are comprised of leucocytes that accumulate in the perivascular space around post-capillary venules before their infiltration into the parenchyma of the central nervous system. Inflammatory perivascular cuffs are commonly found in the central nervous system of patients

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