추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
predicted mol wt 111 kDa
종 반응성
human, mouse, rat
기술
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... KL(9365)
일반 설명
The gene KL (klotho) encodes a protein that has homology to β-glucosidase enzymes. The gene is mapped to human chromosome 13q12. The gene transcript spans a length of 5.2kb. Alternative splicing leads to the generation of two forms, a transmembrane and a secreted form. The transmembrane protein contains 1014 amino acids.
면역원
KLOTHO antibody was raised against a 16 amino acid peptide near the center of human KLOTHO.
애플리케이션
Anti-KL antibody produced in rabbit has been used as a primary antibody in immunoblot technique.
생화학적/생리학적 작용
The KL (klotho) gene is also referred to as an anti-aging gene as it encodes a senescence-related molecule. It regulates fibroblast growth factor (FGF) 23 signaling by functioning as a cofactor or coreceptor. It is involved in the activation of TRPV5 (transient receptor potential cation channel subfamily V member 5), an ion channel, by functioning as a glucuronidase. Klotho affects several intracellular signaling pathways, such as p53/p21, cAMP, protein kinase C (PKC) and Wnt signaling pathways. Mutations in this gene have been associated with premature aging-like phenotypes and shortened life span. Single nucleotide polymorphisms in this gene have been associated with priapism in sickle cell anaemia.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
결합
The action of this antibody can be blocked using blocking peptide SBP3500604.
물리적 형태
Supplied in PBS with 0.02% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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관련 제품
Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Hong Su et al.
International journal of general medicine, 15, 7885-7893 (2022-10-29)
This study focused on renal arteriosclerosis and aimed to explore the relationship between Klotho and SIRT1 by morphological staining, which will help to provide new ideas for the treatment of renal-aging-related diseases and a theoretical basis for the development of
Astragaloside IV Attenuates High-Glucose-Induced Impairment in Diabetic Nephropathy by Increasing Klotho Expression via the NF-I?B/NLRP3 Axis.
He, et al.
Journal of Diabetes Research, 2023, 7423661-7423661 (2023)
Agnieszka Olejnik et al.
Journal of cellular and molecular medicine, 24(11), 6448-6458 (2020-04-23)
Restoration of blood flow to ischaemic heart inflicts ischaemia/reperfusion (I/R) injury, which manifests in metabolic and morphological disorders. Klotho is a protein with antioxidative and antiapoptotic activity, and is involved in the regulation of inflammation and fibrosis. The aim of
Chiao-Yin Sun et al.
Genes, 11(9) (2020-09-10)
The Klotho gene functions as an anti-aging gene. A previous klotho-knockout mice study indicated that neither male nor female gametocytes could accomplish the first meiotic division. It suggested that Klotho might regulate cell division. In this study, we determined the
Current understanding of klotho.
Wang Y and Sun Z
Ageing Research Reviews, 8, 43-51 (2009)
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