SAB4200736

Anti-S100-A10 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• 동의어(들): Anti-ANX2LG, Anti-CAL1L, Anti-CLP11
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 항체 형태: IgG fraction of antiserum
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: ~11 kDa
• 종 반응성: human
• 기술: immunoblotting: 1:500-1:1000 using human epidermoid carcinoma A431 cell line extract; immunohistochemistry: 1:500-1:1000 using heat-retrieved formalin-fixed, paraffin-embedded Human Pancrease carcinoma sections
• UniProt 수납 번호: P60903
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... S100A10(6281)

설명

일반 설명

S100 calcium binding protein A10 (S100-A10), also known as calpactin I light chain or p11 or cellular ligand of annexin II, is a member of the S100 family of proteins. S100-A10 is mapped to human chromosome 1q21.3 and is expressed in the intestine, lungs and kidney. It contains two EF-hand calcium-binding motifs.

특이성

Anti-S100-A10 recognizes human S100-A10.

면역원

synthetic peptide corresponding to a sequence at the N-terminus of human S100-A10, conjugated to KLH

애플리케이션

Anti-S100-A10 antibody produced in rabbit may be used in immunoblotting and immunohistochemistry.

생화학적/생리학적 작용

S100 calcium binding protein A10 (S100-A10) functions as the regulatory subunit of Annexin II (ANX2) to generate the active heterotetramer ANX2/p11 (ANX2T). S100-A10 is implicated in prostate cancer and multiple myeloma and enables cells to reach adhesion and growth at the bone marrow microenvironment. Elevated levels of S100-A10 are observed in squamous non-cell lung cancer, anaplastic large cell lymphoma, renal cell carcinoma and pediatric intracranial ependymoma. Experimental evidence implicates S100-A10 involvement in the mechanism of action of antidepressant drugs and electroconvulsive seizures due to its interaction with specific serotonin receptors.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

저장 및 안정성

Store at –20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

면책조항

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable