SAB4300032

Anti-phospho-STAT1 (pTyr⁷⁰¹) antibody produced in rabbit

affinity isolated antibody

• 동의어(들): Anti-DKFZp686B04100 antibody produced in rabbit, Anti-ISGF-3 antibody produced in rabbit, Anti-STAT91 antibody produced in rabbit, Anti-signal transducer and activator of transcription 1, 91kDa antibody produced in rabbit
• MDL number: MFCD01633987
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: ~91 kDa
• 종 반응성: human, mouse
• 농도: 1 mg/mL
• 기술: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• 동형: IgG
• 면역원 서열: (T-G-YP-I-K)
• NCBI 수납 번호: NP_009330.1
• UniProt 수납 번호: P42224
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pTyr701)
• 유전자 정보: human ... STAT1(6772)

설명

일반 설명

Signal transducer and activator of transcription 1 (STAT1) gene is mapped to human chromosome 2q32.2. It is part of the STAT family of proteins. STAT1 exists in two isoforms, STAT1α and STAT1β with molecular weight of 91kDa and 84kDa, respectively. The protein shows ubiquitous expression.

면역원

Peptide sequence around phosphorylation site of tyrosine 701 (T-G-Y(p)-I-K), according to the protein STAT1.

생화학적/생리학적 작용

Signal transducer and activator of transcription 1 (STAT1) plays a vital role in interferon (IFN) signaling. Phospho-STAT1 regulates pro- and anti-apoptotic genes following several stress-induced responses. It interacts with p53 and promotes p53-mediated transcriptional gene activity and apoptosis. STAT1 is also an essential factor of stress-induced and DNA damage-induced checkpoint pathways and thus, acts as a tumor suppressor.

특징 및 장점

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물리적 형태

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable