추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous glycerol solution
종 반응성
human, mouse, rat
기술
immunohistochemistry: 1:20-1:100
western blot: 1:500-1:2000
수납 번호(accession number)
NP_001888
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... CSPG4(1464)
일반 설명
Chondroitin sulfate proteoglycan 4 (CSPG4) is commonly known as Melanoma chondroitin sulphate proteoglycan (MCSP). MCSP is a transmembrane protein. MCSP is lower in normal melanocytes. In human chromosome, the gene CSPG4 is localized on 15q24.2.
면역원
Synthetic peptide corresponding to residues near the C terminal of human chondroitin sulfate proteoglycan 4
생화학적/생리학적 작용
Chondroitin sulfate proteoglycan 4 (CSPG4) is a cell surface antigen, expressed in most human melanoma and is crucial for tumour progression and invasion. MCSP activates cell division control protein 42 homolog (Cdc42) and Cdc42-associated tyrosine kinase-1 (Ack-1) to form complex, which signals and leads to melanoma progression and metastasis. The complex of MCSP with membrane-type 3 matrix metalloproteinase (MT3-MMP) signals melanoma invasion and proteolysis. MCSP is associated with angiogenesis dependent processes like tumor growth and healing of wound. MCSP plays a key role in regulating chondrosarcoma and provides resistance to chemotherapy. CSPG4 is a prognostic marker for glioblastoma.
특징 및 장점
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물리적 형태
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas
Eisenmann KM, et al.
Nature Cell Biology, 1(8), 507-513 (1999)
Functional roles of CSPG4/NG2 in chondrosarcoma
Jamil NS, et al.
International Journal of Experimental Pathology, 97(2), 178-186 (2016)
Gene expression signature associated with BRAF mutations in human primary cutaneous melanomas
Kannengiesser C, et al.
Molecular Oncology, 1(4), 425-430 (2008)
Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma
Svendsen A, et al.
Acta Neuropathologica, 122(4), 495-510 (2011)
A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family
Staub E, et al.
Febs Letters, 527(1-3), 114-118 (2002)
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