SAB4503051

Anti-Tyrosinase antibody produced in rabbit

affinity isolated antibody

• 동의어(들): LB24-AB, Monophenol monooxygenase, SK29-AB, TYR, Tumor rejection antigen AB
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: antigen 60 kDa
• 종 반응성: human
• 농도: ~1 mg/mL
• 기술: ELISA: 1:10000; western blot: 1:500-1:1000
• NCBI 수납 번호: P14679
• UniProt 수납 번호: P14679
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... TYR(7299)

설명

일반 설명

Anti-Tyrosinase Antibody detects endogenous levels of total Tyrosinase protein.

The TYR (tyrosinase) gene is mapped to human chromosome 11q14.3 and codes for a membrane glycoprotein, tyrosinase. It is ubiquitously expressed in plant and animal tissue.

면역원

The antiserum was produced against synthesized peptide derived from human Tyrosinase.

Immunogen Range: 471-520

생화학적/생리학적 작용

The encoded protein, tyrosinase, is involved in melanin production by catalyzing the oxidation of L-tyrosine and L- 3, 4-dihydroxyphenylalanine to form dopaquinone. TYR (tyrosinase) is associated with the development of neural crest cell into melanocytes. Biallelic mutations in the TYR gene results in an autosomal recessive disorder, oculocutaneous albinism type 1. Loss of tyrosinase activity contributes to the severity of this disorder, in which melanin is undetectable. Abnormal expression of the gene has been observed in atypical fibroxanthoma.

특징 및 장점

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물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable