추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
whole antiserum
항체 생산 유형
primary antibodies
클론
polyclonal
포함
15 mM sodium azide
종 반응성
chicken, rat, mouse
기술
western blot: 1:100 using rat or mouse brain tissue extract
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... MAPT(4137)
일반 설명
Tau (τ), also known as MAPT (microtubule associated protein tau) is encoded by the gene mapped on human chromosome 17q21.3. It is highly expressed in neurons but is most prominent in axons.
Tau (τ), also known as microtubule associated protein tau (MAPT) is encoded by the gene mapped on human chromosome 17q21.3. It is highly expressed in neurons but is most prominent in axons. Tau is a heat stable microtubule associated protein (MAP) with a molecular weight of 55- 65 kDa.
특이성
The antibody shows wide species reactivity. Anti-τ does not react with MAP1, MAP2 or tubulin. the antibody reacts with τ, one of the two major classes of heat stable microtubule-associated proteins (MAPs).
면역원
τ proteins from chicken embryo brain microtubules.
애플리케이션
Anti-τ (Tau) antibody produced in rabbit has been used as a primary antibody in western blotting.
생화학적/생리학적 작용
Removal of Tau (τ) results in developmental delay and learning disability. It participates in the pathology of Alzheimer′s disease (AD). Tau helps in the assembly and maintenance of microtubule structure.
Variation in the MAPT gene encoding tau protein results in frontotemporal dementia. Tau protein acts as a substrate for many kinases.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
J H Su et al.
Acta neuropathologica, 96(5), 463-471 (1998-11-26)
Plaque-associated dystrophic neurites are a common pathological feature in the brains of patients with Alzheimer's disease (AD). In the present study, we investigated the relative abundance and progressive transformation of the amyloid precursor protein (APP), neurofilament (NF) and paired helical
M F DeFreitas et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(14), 5121-5129 (2001-07-05)
Subplate neurons of mammalian neocortex undergo pronounced cell death postnatally, long after they have matured and become incorporated into functional cortical circuits. They express the p75 neurotrophin receptor (p75NTR), which is known to signal cell death in some types of
Tau pathology in Alzheimer disease and other tauopathies
Iqbal K, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1739(2-3), 198-210 (2005)
Michael Briese et al.
Nucleic acids research, 44(4), e33-e33 (2015-10-16)
Most RNAs within polarized cells such as neurons are sorted subcellularly in a coordinated manner. Despite advances in the development of methods for profiling polyadenylated RNAs from small amounts of input RNA, techniques for profiling coding and non-coding RNAs simultaneously
Lieven Declercq et al.
Molecular imaging, 15 (2016-04-01)
Early clinical results of two tau tracers, [(18)F]T808 and [(18)F]T807, have recently been reported. In the present study, the biodistribution, radiometabolite quantification, and competition-binding studies were performed in order to acquire comparative preclinical data as well as to establish the
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