추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen 58 kDa
종 반응성
mouse, rat, human
농도
~1 mg/mL
기술
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
phosphorylation (pTyr135)
유전자 정보
human ... KCNA3(3738)
일반 설명
The voltage-dependent potassium channel (Kv1.3/KCNA3) is expressed in the nervous and immune systems. This gene is located on human chromosome 1p13.
면역원
The antiserum was produced against synthesized peptide derived from human Kv1.3/KCNA3 around the phosphorylation site of Tyr135.
Immunogen Range: 101-150
Immunogen Range: 101-150
생화학적/생리학적 작용
The voltage-dependent potassium channel (Kv1.3/KCNA3) plays a major role in setting the resting membrane potential, cell proliferation, apoptosis and volume regulation. This protein participates in immunomodulation of autoreactive effector and memory T cell-mediated autoimmune diseases. KCNA3 is required for T-cell proliferation and activation.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Polymorphism in the KCNA3 gene is associated with susceptibility to autoimmune pancreatitis in the Japanese population.
Ota M, et al.
Disease Markers, 31(4), 223-229 (2011)
The voltage-gated potassium channel Kv1. 3 is a promising multitherapeutic target against human pathologies.
Perez-Verdaguer M, et al.
Expert Opinion on Therapeutic Targets, 20(5), 577-591 (2016)
Inhibition of Kv1. 3 channels in human jurkat T cells by xanthohumol and isoxanthohumol.
Gasiorowska J, et al.
The Journal of Membrane Biology, 248(4), 705-711 (2015)
Souvarish Sarkar et al.
The Journal of clinical investigation, 130(8), 4195-4212 (2020-07-01)
Characterization of the key cellular targets contributing to sustained microglial activation in neurodegenerative diseases, including Parkinson's disease (PD), and optimal modulation of these targets can provide potential treatments to halt disease progression. Here, we demonstrated that microglial Kv1.3, a voltage-gated
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