콘텐츠로 건너뛰기
Merck
모든 사진(1)

주요 문서

모든 문서 보기

SMB00708

Sigma-Aldrich

Lysobactin

≥97% (HPLC)

동의어(들):

Katanosin B, L-Serine, D-leucyl-L-leucyl-(βR)-β-hydroxy-L-phenylalanyl-(3R)-3-hydroxy-L-leucyl-L-leucyl-D-arginyl-L-isoleucyl-L-allothreonylglycyl-(3S)-3-hydroxy-L-asparaginyl-, (11→3)-lactone

로그인조직 및 계약 가격 보기
모든 사진(1)

About This Item

실험식(Hill 표기법):
C58H97N15O17 · xC2H4O2
CAS Number:
118374-47-3
Molecular Weight:
1276.48 (free base basis)
UNSPSC 코드:
41116107
NACRES:
NA.76

Quality Level

200

분석

≥97% (HPLC)

양식

powder

구성

counterion (acetate salt)

solubility

DMSO: 1 mg/mL

항생제 활성 스펙트럼

Gram-negative bacteria
Gram-positive bacteria

동작 모드

cell wall synthesis | interferes

저장 온도

−20°C

SMILES string

N1[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)OC([C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C1=O)[C@H](CC)C)CCCN=C(N)N)CC(C)C)[C@H](O)C(C)C)NC(=O)[C@@H](NC(=O)[C@H](N)CC(C)C)CC(C)C)c2ccccc2)CO)[C@H](O)C(=O)N)[C@@H](O)C.OC(=O)C

InChI

1S/C58H97N15O17.C2H4O2/c1-12-30(10)39-53(85)71-40(31(11)75)52(84)64-24-38(76)69-42(45(78)47(60)79)55(87)68-37(25-74)57(89)90-46(32-17-14-13-15-18-32)43(73-51(83)36(23-28(6)7)66-48(80)33(59)21-26(2)3)56(88)72-41(44(77)29(8)9)54(86)67-35(22-27(4)5)50(82)65-

InChI key

TXXDLVCKZNQGAV-QPXZYOHJSA-N

생화학적/생리학적 작용

Lysobactin is a cyclic peptide with strong antibacterial activity against many bacterial strains including Staphylococcus aureus, Salmonella typhosa, and Klebsiella aerogenes. Lysobactin is reported to have MIC values of 0.2, 25, and 25 μg/mL for the above listed bacteria respectively, which is significantly higher than the potency reported for vancomycin for the same bacteria (MIC values 0.8, >100, and >100 μg/mL respectively).

The mechanism of action of lysobactin is attributed to its interaction with lipid I and lipid II in the bacterial cell wall. Lysobactin forms a 1:1 complex with lipid I and lipid II causing interference in peptidoglycan synthesis which is essential for bacterial viability. Furthermore, lysobactin was not found to be hemolytic at concentrations above its MIC.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
028M4097V
14171210
14171209
TEST

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

이미 열람한 고객

Slide 1 of 2

1 of 2

N,N,N′,N′-Tetramethylethylenediamine BioReagent, suitable for electrophoresis, ≥99.0%

Sigma-Aldrich

T9281

N,N,N′,N′-Tetramethylethylenediamine

Sodium dodecyl sulfate BioReagent, suitable for electrophoresis, for molecular biology, ≥98.5% (GC)

Sigma-Aldrich

L3771

Sodium dodecyl sulfate

D P Bonner et al.
The Journal of antibiotics, 41(12), 1745-1751 (1988-12-01)
Lysobactin, an antibiotic isolated from a strain of Lysobacter, is 2 to 4-fold more active than vancomycin against aerobic and anaerobic Gram-positive bacteria. Included in the spectrum of lysobactin are Staphylococci, Streptococci, corynebacteria, clostridia and various other Gram-positive anaerobic bacteria.
Wonsik Lee et al.
Journal of the American Chemical Society, 138(1), 100-103 (2015-12-20)
Lysobactin, also known as katanosin B, is a potent antibiotic with in vivo efficacy against Staphylococcus aureus and Streptococcus pneumoniae. It was previously shown to inhibit peptidoglycan (PG) biosynthesis, but its molecular mechanism of action has not been established. Using

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

고객지원팀으로 연락바랍니다.