SMB00708

Lysobactin

≥97% (HPLC)

• 동의어(들): Katanosin B, L-Serine, D-leucyl-L-leucyl-(βR)-β-hydroxy-L-phenylalanyl-(3R)-3-hydroxy-L-leucyl-L-leucyl-D-arginyl-L-isoleucyl-L-allothreonylglycyl-(3S)-3-hydroxy-L-asparaginyl-, (11→3)-lactone
• 실험식(Hill 표기법): C₅₈H₉₇N₁₅O₁₇ · xC₂H₄O₂
• CAS Number: 118374-47-3
• Molecular Weight: 1276.48 (free base basis)
• UNSPSC 코드: 41116107
• NACRES: NA.76

속성

• Quality Level: 200
• 분석: ≥97% (HPLC)
• 양식: powder
• 구성: counterion (acetate salt)
• solubility: DMSO: 1 mg/mL
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria
• 동작 모드: cell wall synthesis | interferes
• 저장 온도: −20°C
• SMILES string: N1[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)OC([C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C1=O)[C@H](CC)C)CCCN=C(N)N)CC(C)C)[C@H](O)C(C)C)NC(=O)[C@@H](NC(=O)[C@H](N)CC(C)C)CC(C)C)c2ccccc2)CO)[C@H](O)C(=O)N)[C@@H](O)C.OC(=O)C
• InChI: 1S/C58H97N15O17.C2H4O2/c1-12-30(10)39-53(85)71-40(31(11)75)52(84)64-24-38(76)69-42(45(78)47(60)79)55(87)68-37(25-74)57(89)90-46(32-17-14-13-15-18-32)43(73-51(83)36(23-28(6)7)66-48(80)33(59)21-26(2)3)56(88)72-41(44(77)29(8)9)54(86)67-35(22-27(4)5)50(82)65-
• InChI key: TXXDLVCKZNQGAV-QPXZYOHJSA-N

설명

생화학적/생리학적 작용

Lysobactin is a cyclic peptide with strong antibacterial activity against many bacterial strains including Staphylococcus aureus, Salmonella typhosa, and Klebsiella aerogenes. Lysobactin is reported to have MIC values of 0.2, 25, and 25 μg/mL for the above listed bacteria respectively, which is significantly higher than the potency reported for vancomycin for the same bacteria (MIC values 0.8, >100, and >100 μg/mL respectively).

The mechanism of action of lysobactin is attributed to its interaction with lipid I and lipid II in the bacterial cell wall. Lysobactin forms a 1:1 complex with lipid I and lipid II causing interference in peptidoglycan synthesis which is essential for bacterial viability. Furthermore, lysobactin was not found to be hemolytic at concentrations above its MIC.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable