SML0488
Dobesilate Calcium
≥98% (HPLC)
동의어(들):
2,5-Dihydroxybenzenesulfonic acid calcium salt, 205E, Calcium 2,5-dihydroxybenzenesulfonate, Calcium Dobesilate, Hydroquinone calcium sulfonate
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C6H5O5S · 0.5Ca
CAS Number:
Molecular Weight:
209.20
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
형태
powder
색상
white to beige
solubility
H2O: 15 mg/mL, clear
저장 온도
room temp
SMILES string
[Ca++].Oc1ccc(O)c(c1)S([O-])(=O)=O.Oc2ccc(O)c(c2)S([O-])(=O)=O
InChI
1S/2C6H6O5S.Ca/c2*7-4-1-2-5(8)6(3-4)12(9,10)11;/h2*1-3,7-8H,(H,9,10,11);/q;;+2/p-2
InChI key
QGNBTYAQAPLTMX-UHFFFAOYSA-L
일반 설명
Dobesilate calcium belongs to the family of fibroblast growth factor (FGF) inhibitors.
애플리케이션
Dobesilate calcium has been used to study its interference in different in vitro assay systems for the determination of creatinine, uric acid, cholesterol, and triglycerides.
생화학적/생리학적 작용
Dobesilate Calcium is a vasoprotectant used as a treatment for chronic venous disease, diabetic retinopathy and other microvascular disorders. Its mechanism of action is not fully understood. It appears that dobesilate calcium increases endothelial nitric oxide levels by enhancing the activity of nitric oxide synthase and decreasing capillary hyperpermeability. Also in diabetic retinopathy dobesilate calcium prevents the blood-retinal barrier breakdown induced by diabetes by restoration of the tight junction protein, and decreasing the leukocyte adhesion to retinal vessels.
Dobesilate calcium inhibits the action of fibroblast growth factor by binding to its heparin-binding domain. It is also useful in treating rosacea and psoriasis, characterized with uncontrolled angiogenesis and vascular endothelial growth factor overexpression.
특징 및 장점
This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Therapeutic effects of calcium dobesilate on diabetic nephropathy mediated through reduction of expression of PAI?1.
Zhang X
Experimental and Therapeutic Medicine, 5(1), 295-299 (2013)
Xiuzhi Guo et al.
Medicine, 94(23), e905-e905 (2015-06-11)
The vasoprotective drug calcium dobesilate is known to interfere with creatinine (Cr) quantifications in sarcosine oxidase enzymatic (SOE) assays. The aim of this study was to investigate this interference in 8 different commercially available assays and to determine its clinical
Xiuzhi Guo et al.
Clinica chimica acta; international journal of clinical chemistry, 483, 1-5 (2018-04-14)
We reported that calcium dobesilate, a vasoprotective agent mainly used for diabetic retinopathy (DR), negatively interferes with glycated albumin (GA) assays involving enzymatic methods. A calcium dobesilate standard was added to 3serum pools in vitro to prepare concentration-response series according
Negative interferences by calcium dobesilate in the detection of five serum analytes involving Trinder reaction-based assays.
Guo X, et al.
PLoS ONE, 13(2), e0192440-e0192440 (2018)
Jaimi A Gray et al.
BMC evolutionary biology, 19(1), 7-7 (2019-01-10)
Morphological diversity among closely related animals can be the result of differing growth patterns. The Australian radiation of agamid lizards (Amphibolurinae) exhibits great ecological and morphological diversity, which they have achieved on a continent-wide scale, in a relatively short period
문서
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