SML0716

SB225002

≥98% (HPLC)

• 동의어(들): N-(2-Hydroxy-4-nitrophenyl)-N′-(2-bromophenyl)urea, SB-225002
• 실험식(Hill 표기법): C₁₃H₁₀BrN₃O₄
• CAS Number: 182498-32-4
• Molecular Weight: 352.14
• UNSPSC 코드: 51111800
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: white to beige
• solubility: DMSO: 20 mg/mL, clear
• 저장 온도: room temp
• InChI: 1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
• InChI key: MQBZVUNNWUIPMK-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Blocking action of SB-225002 on CXCR2 (interleukin 8 receptor β), prevents the IL-8 induced matrix metalloproteinase-9 release from neutrophils. Matrix metalloproteinase-9 are proteolytic enzymes associated with inflammation.

SB-225002 is a potent nonpeptide inhibitor of chemokine receptor CXCR2 with an IC₅₀ of 22 nM for inhibiting interleukin IL-8 binding to CXCR2 and > 150-fold selectivity over CXCR1 receptors. CXCR2 binds many different immune cell chemoattractants. SB-225002 is crucial for cancer progression and is involved in inflammatory diseases like COPD, rheumatoid arthritis, and ulcerative colitis.

특징 및 장점

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable