SML1165

Talnetant

≥98% (HPLC)

• 동의어(들): (S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide, SB-223412
• 실험식(Hill 표기법): C₂₅H₂₂N₂O₂
• CAS Number: 174636-32-9
• Molecular Weight: 382.45
• MDL number: MFCD00944075
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825695
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 광학 활성: [α]/D -25 to -31°, c = 0.5 in methanol
• 색상: white to beige
• solubility: DMSO: 25 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: OC(C(C(N[C@H](C1=CC=CC=C1)CC)=O)=C(C=CC=C2)C2=N3)=C3C4=CC=CC=C4
• InChI: 1S/C25H22N2O2/c1-2-20(17-11-5-3-6-12-17)27-25(29)22-19-15-9-10-16-21(19)26-23(24(22)28)18-13-7-4-8-14-18/h3-16,20,28H,2H2,1H3,(H,27,29)/t20-/m0/s1
• InChI key: BIAVGWDGIJKWRM-FQEVSTJZSA-N
• 유전자 정보: human ... TACR3(6870)

설명

생화학적/생리학적 작용

Talnetant (SB-223,412) is a highly selective antagonist of neurokinin 3 receptor with a Ki (NK3) = 1 nM >10000 (NK1) >140 (NK2). Neurokinins (tachykinins) are members of a family of at least three neuropeptides, substance P, neurokinin A, and neurokinin B (NKB), with each mediating their biological effects through binding to a preferred G-protein-coupled receptor termed NK1, NK2, or NK3, respectively. All three NK receptors are expressed in regions of the central nervous system that are related to emotion and cognition (i.e., amygdala and hippocampus) and have been linked to various degrees in psychiatric disorders. Neurokinin receptors, including NK3 receptors, are also expressed in the motor and sensory systems of the digestive tract. Talnetant was in clinical trials for both irritable bowel syndrome and schizophrenia.

특징 및 장점

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안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable