SML1560

Azoramide

≥98% (HPLC)

• 동의어(들): N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]-butanamide, N-{2-[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]ethyl} butanamide
• 실험식(Hill 표기법): C₁₅H₁₇ClN₂OS
• CAS Number: 932986-18-0
• Molecular Weight: 308.83
• MDL number: MFCD08009374
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825964
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 30 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: ClC1=CC=C(C2=NC(CCNC(CCC)=O)=CS2)C=C1
• InChI: 1S/C15H17ClN2OS/c1-2-3-14(19)17-9-8-13-10-20-15(18-13)11-4-6-12(16)7-5-11/h4-7,10H,2-3,8-9H2,1H3,(H,17,19)
• InChI key: VYBFWKKCWTXCQX-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Azoramide is a modulator of the unfolded protein response with antidiabetic activity. It has dual activity: Azoramide improves endoplasmic reticulum (ER) protein-folding ability and stimulates the expression of ER chaperones that protect cells against ER stress. Azoramide was shown to protect cells from death and dysfunction in multiple models of ER stress. It showed antidiabetic activity in two independent mouse models of obesity by improving insulin sensitivity and protecting pancreatic β cell function against ER stress.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable