SML1578

Aftin-4

≥98% (HPLC)

• 동의어(들): (2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, Amyloid-β Forty-Two Inducer 4, N6-Methyl-(R)-roscovitine
• 실험식(Hill 표기법): C₂₀H₂₈N₆O
• CAS Number: 866893-90-5
• Molecular Weight: 368.48
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 저장 조건: protect from light
• 색상: white to beige
• solubility: DMSO: 25 mg/mL, clear
• 저장 온도: −20°C

설명

생화학적/생리학적 작용

Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer′s disease-like toxicity in the rodent brain.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3