R7772

Roscovitine

≥98% (TLC)

• 동의어(들): 2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
• 실험식(Hill 표기법): C₁₉H₂₆N₆O
• CAS Number: 186692-46-6
• Molecular Weight: 354.45
• MDL number: MFCD02266401
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278682
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• 분석: ≥98% (TLC)
• 형태: powder
• mp: 106-107 °C
• solubility: chloroform: 50 mg/mL, clear, colorless to light yellow
• 저장 온도: −20°C
• SMILES string: CC[C@H](CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1
• InChI: 1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
• InChI key: BTIHMVBBUGXLCJ-OAHLLOKOSA-N
• 유전자 정보: human ... CDK1(983) , CDK2(1017) , CDK5(1020) , CDK7(1022) , CDK9(1025) , CDKN1A(1026) , CDKN1B(1027) , CDKN1C(1028) , CDKN2A(1029) , CDKN2B(1030) , CDKN2C(1031) , CDKN2D(1032) , CDKN3(1033) ; mouse ... CDK1(12534) ; rat ... CDK1(54237)

설명

애플리케이션

Roscovitine has been used:

• an inhibitor of p34cdc2/cyclin B kinase to preculture porcine oocytes
• as a supplement in TCM199 medium for in vitro prematuration of cumulus-oocyte complexes (COCs) of adult goats
• in astrocyte conditioned media as an inhibitor of cyclin-dependent kinase 5 (CDK5)
• as a CDK2 inhibitor in culture media to treat hESCs

생화학적/생리학적 작용

Roscovitine is a purine derived inhibitor. It stimulates apoptosis in cancer cells. It has inhibitory action on mitogen activated protein kinase (MAPK) and M-phase promoting factor (MPF) kinase activity. Roscovitine is known to arrest meiosis and thus, prevent embryonic development.

Roscovitine is a potent, selective inhibitor of cyclin-dependent kinases.

특징 및 장점

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

법적 정보

Sold under license from CNRS

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)