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Merck
모든 사진(1)

주요 문서

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SML3056

Sigma-Aldrich

Bevantolol Hydrochloride

≥98% (HPLC)

동의어(들):

1-[(3,4-Dimethoxyphenethyl)amino]-3-(m-tolyloxy)-2-propanol hydrochloride, 2-Propanol,1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-, hydrochloride (1:1), CI 775, Cl 775, NC 1400, Ranestol, Sentiloc, Vantol

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C20H27NO4 · HCl
CAS Number:
42864-78-8
Molecular Weight:
381.89
MDL number:
MFCD00941389
UNSPSC 코드:
12352200
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

형태

powder

저장 조건

desiccated

색상

white to beige

solubility

H2O: 2 mg/mL, clear

저장 온도

2-8°C

SMILES string

OC(COC1=CC=CC(C)=C1)CNCCC2=CC(OC)=C(C=C2)OC.Cl

InChI

1S/C20H27NO4.ClH/c1-15-5-4-6-18(11-15)25-14-17(22)13-21-10-9-16-7-8-19(23-2)20(12-16)24-3;/h4-8,11-12,17,21-22H,9-10,13-14H2,1-3H3;1H

InChI key

FJTKCFSPYUMXJB-UHFFFAOYSA-N

생화학적/생리학적 작용

Bevantolol is orally available, anti-hypertension agent that acted as both a beta blocker and a calcium channel blocker. Bevantolol is a beta 1 (β1) adrenoceptor antagonist with alpha1 (α1)-adrenoceptor partial antagonist activity. Bevantolol had no effect on the beta-adrenoceptor density and their subtype proportions after chronic administration in rats.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H302

예방조치 성명서

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

Takahiro Horinouchi et al.
Life sciences, 81(5), 399-404 (2007-07-14)
Recently, tissue segment binding method with a hydrophilic radioligand [(3)H]-CGP12177 was developed to detect plasma membrane beta-adrenoceptors in rat heart (Horinouchi et al., 2006). In the present study, propranolol (40 mg kg(-1) day(-1)), atenolol (40 mg kg(-1) day(-1)) and bevantolol
Gavin W K Wong et al.
The Cochrane database of systematic reviews, 3, CD007451-CD007451 (2016-03-11)
Beta blockers are commonly used to treat hypertension. The blood pressure reading is the primary tool for physicians and patients to assess the efficacy of the treatment. The blood pressure lowering effect of beta-1 selective blockers is not known. To
Barbara Malinowska et al.
British journal of pharmacology, 139(8), 1548-1554 (2003-08-19)
1. Atypical beta-adrenoceptors resistant to propranolol, but blocked by bupranolol, increase contractile force and/or frequency of the heart in humans and rats. We compared the potencies of the enantiomers of bupranolol and examined the possible effects of seven bupranolol analogues
David J Augeri et al.
Journal of medicinal chemistry, 48(15), 5025-5037 (2005-07-22)
Efforts to further elucidate structure-activity relationships (SAR) within our previously disclosed series of beta-quaternary amino acid linked l-cis-4,5-methanoprolinenitrile dipeptidyl peptidase IV (DPP-IV) inhibitors led to the investigation of vinyl substitution at the beta-position of alpha-cycloalkyl-substituted glycines. Despite poor systemic exposure

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